GLPBio

Indican

Catalog No.: GC62062Purity:>99.00%Synonyms: Indoxyl-β-D-glucoside, NSC 87517, Uroxanthin
COASDSData Sheet
Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin.

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Indican
Cas No.: 487-60-5
10mM (in 1mL DMSO)In Stock
$38.00
1
50 mgIn Stock
$35.00
1
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Description

Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4[1][2].

Indican ((Indoxyl-β-D-glucoside; oral; 20, 40 mg/kg; single dose) increases the systemic exposure and MRT of MTX through inhibition on multiple anion transporters including OAT 1, OAT 3 and MRP 4 by the major metabolite IS[1].

[1]. Shiuan-Pey Lin, et al. Transporter-mediated interaction of indican and methotrexate in rats. J Food Drug Anal. 2018 Apr;26(2S):S133-S140.
[2]. Yu-Chi Hou, et al. Indoxyl sulfate, a uremic toxin, is biotransformed from indoxyl-beta-D-glucoside (indican) in rats. Toxicon. 2008 Sep 1;52(3):440-4.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
487-60-5
Synonyms
Indoxyl-β-D-glucoside, NSC 87517, Uroxanthin
SMILES
O[C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O)OC2=CNC3=C2C=CC=C3)CO
Molecular Formula
C14H17NO6
Molecular Weight
295.29
Solubility
DMSO : 100 mg/mL (338.65 mM)|Methanol : 83.33 mg/mL (282.20 mM)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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