iso-ADP ribose TEA is the small-molecule ligand for protein nucleic acid modification, comprising parts of two consecutive ADP-ribosyl units within the PAR chain. iso-ADP ribose TEA specifically binds WWE, FHA and OB-fold domains, enabling PAR-dependent functional responses like ubiquitylation and supporting DNA damage signaling and repair. iso-ADP ribose TEA can be used for cancer research [1].
In Vitro, iso-ADP ribose TEA specifically binds WWE domains in specific human proteins with sub-micromolar affinity, enabling PAR-dependent functional responses like ubiquitylation[1]. iso-ADP ribose TEA specifically binds FHA domains of human APTX and PNKP to support DNA damage signaling and repair[1]. iso-ADP ribose TEA specifically binds OB-fold domains of human SSB1 and BRCA2 to mediate early recruitment to DNA break sites[1].
References:
[1]. Teloni F, et al. Readers of poly(ADP-ribose): designed to be fit for purpose. Nucleic Acids Res. 2016;44(3):993-1006.
In Vitro, iso-ADP ribose TEA specifically binds WWE domains in specific human proteins with sub-micromolar affinity, enabling PAR-dependent functional responses like ubiquitylation[1]. iso-ADP ribose TEA specifically binds FHA domains of human APTX and PNKP to support DNA damage signaling and repair[1]. iso-ADP ribose TEA specifically binds OB-fold domains of human SSB1 and BRCA2 to mediate early recruitment to DNA break sites[1].
References:
[1]. Teloni F, et al. Readers of poly(ADP-ribose): designed to be fit for purpose. Nucleic Acids Res. 2016;44(3):993-1006.