AE-3763 |
| カタログ番号GC32016 |
AE-3763 は、IC50 が 29 nM のペプチドベースのヒト好中球エラスターゼ阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 291778-77-3
Sample solution is provided at 25 µL, 10mM.
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AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.
AE-3763 exhibits potent in vitro inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water[1].
Edema and leukocytes infiltration into the lung are significantly inhibited by infusion of AE-3763. AE3763 significantly improves survival rate by 24 h in a mouse model of fatal shock associated with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when given intravenously by infusion (ED50: 0.42 mg/kg/h) or by bolus injection (1.2 mg/kg). With regard to the toxicity of AE-3763 in mice, the results of a preliminary study have shown no overt toxic effect even at the high dose of 300 mg/kg, iv[1].
[1]. Inoue Y, et al. Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury. Bioorg Med Chem. 2009 Nov 1;17(21):7477-86.
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