Desaminotyrosine (3-(4-Hydroxyphenyl)propionic acid) |
| カタログ番号GC33930 |
デスアミノチロシン (3-(4-ヒドロキシフェニル) プロピオン酸) は、I 型インターフェロン シグナル伝達の増強を通じてインフルエンザから保護する微生物関連代謝産物です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 501-97-3
Sample solution is provided at 25 µL, 10mM.
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Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.
Wild-type mice produce nanomoles of Desaminotyrosine per gram of feces and have picomolar quantities of Desaminotyrosine in the serum. Desaminotyrosine (200 mM) treatment before influenza infection, protects from influenza by type I interferon (IFN) signaling, with no effect on weight loss or survival in mice with or without vancomycin, neomycin, ampicillin, and metronidazole (VNAM). Desaminotyrosine enhances type I IFN in macrophages via type I IFN amplification in mice[1].
[1]. Steed AL, et al. The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science. 2017 Aug 4;357(6350):498-502.
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