Gamma-glutamylcysteine (TFA) (Synonyms: γ-Glutamylcysteine TFA) |
| カタログ番号GC36106 |
γ-グルタミルシステイン (γ-グルタミルシステイン) グルタチオン (GSH) 合成の中間体である TFA は、抗酸化酵素グルタチオンペルオキシダーゼ (GPx) の必須補因子として機能するジペプチドです。
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Cas No.: 283159-88-6
Sample solution is provided at 25 µL, 10mM.
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Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine (TFA) also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes[1]. IL-10 IL-6 IL-1β TNF-α
[1]. Braidy N, et al. The Precursor to Glutathione (GSH), γ-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by Aβ40 Oligomers in Human Astrocytes. Front Aging Neurosci. 2019 Aug 8;11:177.
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