Allethrin (Synonyms: NSC 11782, RU 27436) |
| カタログ番号GC40476 |
ピレスロイド系殺虫剤であるアレスリンは、主要な蚊忌避剤です。アレスリンは、ラット精巣癌細胞 (LC540) で酸化ストレス、アポトーシス、およびカルシウム放出を誘導します。アレスリンは、BCL-2、カスパーゼ-3 の活性化および細胞内カルシウムの放出を誘導します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 584-79-2
Sample solution is provided at 25 µL, 10mM.
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Allethrin is a pyrethroid insecticide and modulator of voltage-gated sodium channels (NaV). It delays channel deactivation in cockroach giant axons when used at a concentration of 1 μM. Allethrin is 100-fold more potent at insect than rat NaV1.8 channels expressed in Xenopus oocytes. It decreases egg production by and is lethal to mosquitoes (LC50 = 0.01%). Allethrin induces production of reactive oxygen species (ROS), lipid peroxidation, and apoptosis in rat primary Leydig cells. In vivo, the smoke of an allethrin-based mosquito coil increases levels of the hepatic enzymes ALT and AST and induces hepatocyte apoptosis as well as emphysema and lung hyperplasia in mice.
| Cas No. | 584-79-2 | SDF | |
| 同義語 | NSC 11782, RU 27436 | ||
| Canonical SMILES | C/C(C)=C/C1C(C)(C)C1C(OC2C(C)=C(CC=C)C(C2)=O)=O | ||
| Formula | C19H26O3 | M.Wt | 302.4 |
| 溶解度 | Chloroform: Slightly Soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.3069 mL | 16.5344 mL | 33.0688 mL |
| 5 mM | 0.6614 mL | 3.3069 mL | 6.6138 mL |
| 10 mM | 0.3307 mL | 1.6534 mL | 3.3069 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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