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APS-2-79 (Standard)

カタログ番号GC81733 Copy One-Click Copy Product Info

APS-2-79 (Standard) is the analytical standard of APS-2-79.

Products are for research use only. Not for human use. We do not sell to patients.

APS-2-79 (Standard) 化学構造

Cas No.: 2002381-25-9

サイズ 価格 在庫数 個数
5mg
$117.00
在庫あり
10mg
$176.00
在庫あり
25mg
$351.00
在庫あり
50mg
$563.00
在庫あり
100mg
$900.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.



Description of APS-2-79 (Standard)

APS-2-79 (Standard) is the analytical standard of APS-2-79. This product is intended for research and analytical applications. APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling.

References:
[1]. Dhawan NS, et al. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature. 2016 Aug 24;537(7618):112-116.

Chemical Properties of APS-2-79 (Standard)

Cas No. 2002381-25-9 SDF
Formula C23H21N3O3 M.Wt 387.43
溶解度 Storage Store at -20°C
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of APS-2-79 (Standard)

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.5811 mL 12.9056 mL 25.8111 mL
5 mM 516.2 μL 2.5811 mL 5.1622 mL
10 mM 258.1 μL 1.2906 mL 2.5811 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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