BAY-7728 |
カタログ番号GC79154
One-Click Copy Product Info
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BAY-7728 is an orally active and selective dual inhibitor of KAT6A ( IC50: 45 nM)/ KAT6B ( IC50: 95 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2767642-46-4
Sample solution is provided at 25 µL, 10mM.
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In Vivo, BAY-7728 (2.5-100 mg/kg; oral administration; once daily; 22 days) reduces intratumoral H3K23ac levels and inhibits tumor growth in a dose-dependent manner without obvious dose-limiting toxicity in NMRI nude mice bearing LCLC-97TM1 human lung cancer xenografts.
In Vitro, BAY-7728 exhibits IC50 values of 55 nM and 164 nM against MVLN and ZR75-1 cells, respectively.
| Cas No. | 2767642-46-4 | SDF | |
| Formula | C20H19FN2O5S | M.Wt | 418.44 |
| 溶解度 | DMSO: 50 mg/mL (119.49 mM; Need ultrasonic) | Storage | Store at 4°C, away from moisture |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.3898 mL | 11.9491 mL | 23.8983 mL |
| 5 mM | 478 μL | 2.3898 mL | 4.7797 mL |
| 10 mM | 239 μL | 1.1949 mL | 2.3898 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)