Cyclo CKLIIF is a dual inhibitor for poxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains KD of 2.6 and 2.2 μM, respectively.
References:
[1]. Ball AT, et al., Identification and Development of Cyclic Peptide Inhibitors of poxia Inducible Factors 1 and 2 That Disrupt poxia-Response Signaling in Cancer Cells. J Am Chem Soc. 2024 Mar 19.