D-3263 |
| カタログ番号GC33158 |
D-3263 は、潜在的な抗腫瘍活性を持つ一過性受容体潜在メラスタチン メンバー 8 (TRPM8) のアゴニストです。
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Cas No.: 947257-66-1
Sample solution is provided at 25 µL, 10mM.
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D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.
D-3263 induces calcium flux and cell death in in vitro cells expressing TRPM8[1].
D-3263 (50 or 100 mg/kg/d) alone or with Finasteride (10 mg/kg/d) results in reduction in prostate hyperplasia of rats with evidence of a dose response. The highest dose of the TRPM8 agonist D-3263, given in combination with Finasteride, results in lower prostate weights than the highest dose of D-3263 or Finasteride given alone, suggesting a potential additive effect[1].
[1]. David Duncan, et al. PRECLINICAL EVALUATION OF THE TRPM8 ION CHANNEL AGONIST D-3263 FOR BENIGN PROSTATIC HYPERPLASIA. THE JOURNAL OF UROLOGY, Vol. 181, No. 4, Supplement, Tuesday, April 28, 2009
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