DPBQ |
カタログ番号GC33384 |
DPBQ は p53 を活性化し、倍数体特異的な方法でアポトーシスを引き起こしますが、トポイソメラーゼを阻害したり DNA に結合したりしません。 DPBQ は p53 の発現とリン酸化を誘発し、この効果は 4 倍体細胞に特異的です。
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Cas No.: 7029-89-2
Sample solution is provided at 25 µL, 10mM.
DPBQ is a p53 activator.
DPBQ elicits apoptosis and cell death and is selective for effects in 4N cells. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells. Knockdown of TP53 restores proliferation of tetraploid cells in the presence of DPBQ[1].
[1]. Choudhary A, et al. Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer. Mol Cancer Ther. 2016 Jan;15(1):48-59.
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