ARN14988 |
| カタログ番号GC42854 |
ARN14988 は酸性セラミダーゼ (ACDase) の強力な阻害剤です (ヒト酵素の IC50 = 12.8 nM)。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1502027-70-4
Sample solution is provided at 25 µL, 10mM.
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ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 µM, respectively).
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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