DSPE-PEG(2000)-mannose is a PEGylated and mannosylated form of 1,2-distearoyl-rac-glycero-3-PE (DSPE) that has been used in the generation of liposomes and mixed micelles for the delivery of anticancer agents to tumor-associated macrophages (TAMs) in vitro and in vivo.1,2 Fluorescently labeled mixed micelles containing DSPE-PEG(2000)-mannose selectively accumulate in the liver and tumor in a 4T1 murine mammary carcinoma model.2 Mixed micelles containing DSPE-PEG(2000)-mannose and encapsulating dasatinib decrease the viability of TAMs isolated from a 4T1 mammary tumor but not RAW 264.7 macrophages. DSPE-PEG(2000)-mannose-containing and dasatinib-encapsulating mixed micelles also reduce tumor volume in a 4T1 murine mammary carcinoma model.
References:
[1]. Peng, H., Chen, B., Huang, W., et al.Reprogramming Tumor-Associated Macrophages To Reverse EGFRT790M Resistance by Dual-Targeting Codelivery of Gefitinib/VorinostatNano Lett.17(12)7684-7690(2017).
[2]. Zhang, X., Zang, X., Qiao, M., et al.Targeted delivery of dasatinib to deplete tumor-associated macrophages by mannosylated mixed micelles for tumor immunotherapyACS Biomater. Sci. Eng.6(10)5675-5684(2020).