PQM130 |
| カタログ番号GC36954 |
PQM130 は、脳に浸透するフェルロイル-ドネペジル ハイブリッド化合物であり、Aβ1-42 オリゴマー (AβO) によって誘発される神経毒性に対する多標的薬剤候補であり、抗炎症活性を示します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2089415-51-8
Sample solution is provided at 25 µL, 10mM.
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PQM130, a Feruloyl-Donepezil Hybrid compound with brain penatration, is a multitarget drug candidate against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 acts as a neuroprotective compound for anti-AD drug development[1].
PQM130 (0.5-1 mg/kg, i.p., daily for 10 days) treatment after the i.c.v. AβO injection reduces oxidative damage and neuroinflammation and induces cell survival and protein synthesis through the modulation of GSK3β and extracellular signal-regulated kinases (ERK1/2) [1]. Animal Model: Adult male C57Bl/6 mice (9 weeks old, 25-30 g body weight) [1].
[1]. Morroni F, et al. PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's Disease. Front Pharmacol. 2019 Jun 12;10:658.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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