β-Amyrin (Synonyms: (+)-β-Amyrin, NSC 527971, Olean-12-en3β-ol) |
| カタログ番号GC45603 |
β- トマト果実とタンポポ コーヒーの表面ワックスの成分であるアミリンは、アミロイド β (Aβ) 誘発性の長期増強 (LTP) 障害をブロックします。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 559-70-6
Sample solution is provided at 25 µL, 10mM.
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β-Amyrin is a natural pentacyclic triterpenoid commonly found in plants. It is a member of the oleanane group of secondary metabolites biosynthesized from squalene in the triterpenoid pathway. β-Amyrin inhibits collagen-induced platelet aggregation (IC50 = 10.5 μM), inhibits acetylcholinesterase (IC50 = 165 μM), and has antifungal and hepatoprotective effects.1,2,3,4 Extracts of certain plants, used in herbal medicine to treat inflammation, have been shown to contain β-amyrin, suggesting that this compound contributes to anti-inflammatory actions.5
References
1. Ching, J., Chua, T.K., Chin, L.C., et al. Beta-amyrin from Ardisia elliptica Thunb. is more potent than aspirin in inhibiting collagen-induced platelet aggregation. Indian J. Exp. Biol. 48(3), 275-279 (2010).
2. Jabeen, K., Javid, A., Ahmad, E., et al. Antifungal compounds from Melia azedarach leaves for management of Ascochyta rabiei, the cause of chickpea blight. Nat. Prod. Res. 25(3), 264-276 (2011).
3. Oliveira, F.A., Chaves, M.H., Almeida, F.R., et al. Protective effect of alpha- and beta-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. trunk wood resin, against acetaminophen-induced liver injury in mice. J. Ethnopharmacol. 98(1-2), 103-108 (2005).
4. Park, S.J., Ahn, Y.J., Oh, S.R., et al. Amyrin attenuates scopolamine-induced cognitive impairment in mice. Biol. Pharm. Bull. 37(7), 1207-1213 (2014).
5. Ferraz-Filha, Z.S., de Paula Michel AraÚjo, M.C., Ferrari, F.C., et al. Tabebuia roseoalba: In vivo hypouricemic and anti-inflammatory effects of its ethanolic extract and constituents. Planta Med. 82(16), 1395-1402 (2016).
| Cas No. | 559-70-6 | SDF | |
| 同義語 | (+)-β-Amyrin, NSC 527971, Olean-12-en3β-ol | ||
| Canonical SMILES | CC1(C)[C@]2([H])CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CCC(C)(C)C[C@@]5([H])C4=CC[C@]3([H])[C@@]2(C)CC[C@@H]1O | ||
| Formula | C30H50O | M.Wt | 426.7 |
| 溶解度 | DMF: 3 mg/ ml,DMF:PBS (pH 7.2) (1:8): 0.11 mg/ml,Ethanol: 1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.3436 mL | 11.7178 mL | 23.4357 mL |
| 5 mM | 0.4687 mL | 2.3436 mL | 4.6871 mL |
| 10 mM | 0.2344 mL | 1.1718 mL | 2.3436 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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