KDM4C-IN-2 is a histone lysine demethylase KDM4C ( JMJD2C ) inhibitor with an IC50 of 147 μM and a K i of 51 μM. KDM4C-IN-2 can be used for the research of cancer, such as prostate and breast cancer [1].
In Vitro, KDM4C-IN-2 (Compound 2) (0.01-500 μM) shows no inhibitory effect on FDH[1].
References:
[1]. Leurs U, et al. Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C). Bioorg Med Chem Lett. 2012 Sep 15;22(18):5811-3.
In Vitro, KDM4C-IN-2 (Compound 2) (0.01-500 μM) shows no inhibitory effect on FDH[1].
References:
[1]. Leurs U, et al. Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C). Bioorg Med Chem Lett. 2012 Sep 15;22(18):5811-3.