L67 (Synonyms: DNA Ligase Inhibitor) |
カタログ番号GC18186 |
L67 (DNA Ligase Inhibitor) は競合的 DNA リガーゼ阻害剤であり、DNA リガーゼ I/III を効果的に阻害します (どちらの IC50 も 10 μM)。 L67 (DNA Ligase Inhibitor) は、ミトコンドリア DNA のレベルを低下させ、ミトコンドリアで生成された ROS のレベルを増加させることにより、核 DNA 損傷を引き起こす可能性があります。 L67 (DNA Ligase Inhibitor) は、がん細胞のカスパーゼ 1 依存性アポトーシス経路も活性化し、がん研究に使用できます。
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Cas No.: 325970-71-6
Sample solution is provided at 25 µL, 10mM.
L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 uM for human DNA ligase I and human ligase IIIβ). It blocks DNA binding (Ki = 10 uM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIα and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells. It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 uM.
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