MARK4 inhibitor 2 is an inhibitor of microtubule affinity-regulating kinase 4 (MARK4) with an Km of 6.3×10 7 and an IC50 of 0.82 μM. MARK4 inhibitor 2 inhibits the growth of human cells and can be used for cancer research.
MARK4 inhibitor 2 (Compound 23a) (0-20 μM; 24 hour) inhibits the growth of HeLa, U87MG, MDA-MB-435, U251 and HGFs cells with EC50s ranging from 1.76 μM to 7.98 μM[1].
References:
[1]. Maria Voura, et.al. Synthesis, Structural Modification, and Bioactivity Evaluation of Substituted Acridones as Potent Microtubule Affinity-Regulating Kinase 4 InhibitorsACS Pharmacology & Translational Science 2023 6 (7), 1052-1074.