Melagatran |
| カタログ番号GC60240 |
メラガトランは、トロンビン以外の凝固カスケードや線維素溶解酵素の他の酵素と相互作用することなく、トロンビンの直接的かつ経口的に活性な阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 159776-70-2
Sample solution is provided at 25 µL, 10mM.
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Melagatran is a direct and orally active inhibitor of thrombin, without interacting with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin. Melagatran does not require endogenous co-factors for its antithrombin effect and may help to alleviate some of the damaging effects of endotoxemia[1]. Melagatran has the potential to provide a rational approach in the prevention of arterial occlusion[2].
[1]. Eriksson M, et al. Effects of melagatran, a novel direct thrombin inhibitor, during experimental septic shock. Expert Opin Investig Drugs. 2000 May;9(5):1129-37. [2]. Mehta JL, et al. Melagatran, an oral active-site inhibitor of thrombin, prevents or delays formation of electrically induced occlusive thrombus in the canine coronary artery. J Cardiovasc Pharmacol. 1998 Mar;31(3):345-51.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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