MM-589 TFA |
| カタログ番号GC65037 |
MM-589 TFA は、WD リピート ドメイン 5 (WDR5) および混合系統白血病 (MLL) のタンパク質間相互作用の強力な阻害剤です。 MM-589 は 0.90 nM の IC50 で WDR5 に結合し、12.7 nM の IC50 で MLL H3K4 メチルトランスフェラーゼ活性を阻害します。
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Cas No.: 2097887-21-1
Sample solution is provided at 25 µL, 10mM.
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MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1].
MM-589 (0.01-10 µM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations[1].
[1]. Karatas H, et al. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J Med Chem. 2017 Jun 22;60(12):4818-4839.
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