Modimelanotide (ABT-719) acetate is an α-melanocyte-stimulating hormone analog. Modimelanotide acetate has high specific binding ability to melanocortin receptors ( MCR1, 3, 4, 5 ). Modimelanotide acetate possesses anti-inflammatory and organ-protective effects. Modimelanotide acetate can be used in the research of diseases such as acute kidney injury [1] [2].
References:
[1]. Ruiz J. Transferable Mechanisms of Quinolone Resistance from 1998 Onward. Clin Microbiol Rev. 2019 Aug 14;32(4):e00007-19.
[2]. McCullough PA, et al. ABT-719 for the Prevention of Acute Kidney Injury in Patients Undergoing High-Risk Cardiac Surgery: A Randomized Phase 2b Clinical Trial. J Am Heart Assoc. 2016 Aug 20;5(8):e003549.
References:
[1]. Ruiz J. Transferable Mechanisms of Quinolone Resistance from 1998 Onward. Clin Microbiol Rev. 2019 Aug 14;32(4):e00007-19.
[2]. McCullough PA, et al. ABT-719 for the Prevention of Acute Kidney Injury in Patients Undergoing High-Risk Cardiac Surgery: A Randomized Phase 2b Clinical Trial. J Am Heart Assoc. 2016 Aug 20;5(8):e003549.