MONNA |
| カタログ番号GC18358 |
MONNA は、80 nM の IC50 を持つ強力な膜貫通タンパク質 16A (TMEM16A、Anoctamin-1) ブロッカーです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1572936-83-4
Sample solution is provided at 25 µL, 10mM.
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MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 uM in Xenopus oocytes), a calcium-activated chloride channel (CaCC). It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 uM. MONNA (10 uM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride. It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.
Review for MONNA
Average Rating: 5 (Based on Reviews and 13 reference(s) in Google Scholar.)
Review for MONNA
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