NKH 477 (Synonyms: Adehl, Colforsin Dapropate, Colforsin Daropate) |
| カタログ番号GC12640 |
NKH 477 (Colforsin dapropate Hydrochloride) は、アデニル酸シクラーゼの触媒ユニットを直接活性化し、細胞内 cAMP を増加させます。
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Cas No.: 138605-00-2
Sample solution is provided at 25 µL, 10mM.
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NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1].
NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner[1].
References:
[1]. Nakashima S, et al. Antiproliferative effects of NKH477, a forskolin derivative, on cytokine profile in rat lung allografts. J Heart Lung Transplant. 2005 Apr;24(4):462-9.
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