4-hydroxy Nonenal Mercapturic Acid |
カタログ番号GC42413 |
一般的なω-6多価不飽和脂肪酸(PUFA)であるリノール酸、DGLA、およびアラキドン酸の過酸化により4-HNEが生成される可能性があります。
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Cas No.: 146764-24-1
Sample solution is provided at 25 µL, 10mM.
Peroxidation of common ω-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid can give rise to 4-HNE. 4-HNE is cleared rapidly from the plasma and undergoes enterohepatic circulation as a glutathione conjugate in the rat. About two thirds of an administered dose of 4-HNE is excreted within 48 hours in the urine, primarily in the form of mercapturic acid conjugates. The C-1 aldehyde of 4-HNE is reduced to an alcohol in about half of these metabolites. The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids. These aldehydes and carboxylic acids can also form γ-lactols and γ-lactones, respectively, producing at least 4 or 5 end urinary metabolites of 4-HNE in vivo.
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