PDIC-NC is an activator of stimulator of interferon genes (STING) and an anticancer agent.[1],[2] It increases the levels of phosphorylated STING in Lewis lung carcinoma cells when used at a concentration of 2 µM.[1] PDIC-NC decreases the viability of A549 and NCI H446 lung cancer cells (IC50s = 0.48 and 0.79 µg/ml, respectively).[2] It increases the levels of reactive oxygen species (ROS) and decreases the oxygen consumption rate (OCR) in A549 and NCI H446 cells when used at concentrations of 1 and 2 µg/ml, respectively. PDIC-NC selectively accumulates in the lungs over the heart, liver, spleen, and kidneys in mice. Intravenous administration of PDIC-NC (2 mg/kg) reduces tumor volume and the number of metastases in A549 mouse xenograft models.
References:
[1].Zhao, X., Zheng, R., Zhang, B., et al.Sulfonated perylene as three-in-one STING agonist for cancer chemo-immunotherapyAngew. Chem. Int. Ed. Engl.63(11)e202318799(2024).
[2].Liu, Z., Wang, X., Chen, Q., et al.Regulating twisted skeleton to construct organ-specific perylene for intensive cancer chemotherapyAngew Chem. Int. Ed. Engl.60(29)16215-16223(2021).