PF-9363 (Synonyms: CTx-648) |
| カタログ番号GC62247 |
PF-9363 (CTx-648) は、クラス初の強力で選択性の高い KAT6A/KAT6B 阻害剤です。 PF-9363はがんの研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2569009-58-9
Sample solution is provided at 25 µL, 10mM.
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PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer[1][2].
PF-9363 (0~1 μM; 1 day; ZR75-1, T47D and MCF7 cells) down-regulates the expression of H3K23Ac biomarker[1].PF-9363 leads to down regulation of a specific set of genes involved in ESR1 pathway, cell cycle and stem cell pathways. PF-9363 shows that the IC50 values for ZR75-1 and T47D are 0.3 nM and 0.9 nM[1].
PF-9363 shows strong anti-tumor activity in patient-derived xenograft models[1].
[1]. Shikhar S, et al. First-in-class KAT6A/KAT6B Inhibitor CTx-648 (PF-9363) Demonstrates Potent Anti-tumor Activity in ER+ Breast Cancer with KAT6A Dysregulation
[2]. WO2020254946
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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