PGP-4008 |
| カタログ番号GC44615 |
PGP-4008 は、特異的な P 糖タンパク質 (Pgp) 阻害剤です。 PGP-4008 は、ドキソルビシンと組み合わせて投与した場合、マウスの同系 Pgp 媒介性多剤耐性 (MDR) 固形腫瘍モデルにおける腫瘍増殖を阻害します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 365565-02-2
Sample solution is provided at 25 µL, 10mM.
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PGP-4008 is a selective inhibitor of P-glycoprotein (P-gp) that does not affect the activity of multidrug resistance-related protein 1 (MRP1). It is effective in vitro and, when delivered intraperitoneally, in vivo, inhibiting tumor growth when given with doxorubicin . PGP-4008 also enhances the ability of docetaxel to inhibit growth and drive apoptosis in ovarian cancer cells.
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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