Pincainide is a calcium channel inhibitor. Pincainide inhibits voltage-gated calcium channel-mediated calcium influx in smooth muscle. Pincainide inhibits norepinephrine- and high potassium-induced contractile responses. Pincainide can be used in the research of heart diseases [1].
In Vitro, Pincainide (0.5 mM; 5 min) significantly reduces Ca2+-induced contractile responses in K+-depolarized isolated rat aortic strips by inhibiting voltage-gated channel-mediated Ca2+ influx[1]. Pincainide (0.5-5 mM; 10 min) inhibits norepinephrine-stimulated 45Ca influx in isolated rat aortic strips in a dose-dependent manner, with an inhibition rate of 20.8% at 0.5 mM and 47.7% at 5 mM[1].
References:
[1]. Barrigón S, et al. Effects of pincainide on contractile responses and 45Ca movements in rat isolated vascular smooth muscle. Eur J Pharmacol. 1985;111(2):227-233.
In Vitro, Pincainide (0.5 mM; 5 min) significantly reduces Ca2+-induced contractile responses in K+-depolarized isolated rat aortic strips by inhibiting voltage-gated channel-mediated Ca2+ influx[1]. Pincainide (0.5-5 mM; 10 min) inhibits norepinephrine-stimulated 45Ca influx in isolated rat aortic strips in a dose-dependent manner, with an inhibition rate of 20.8% at 0.5 mM and 47.7% at 5 mM[1].
References:
[1]. Barrigón S, et al. Effects of pincainide on contractile responses and 45Ca movements in rat isolated vascular smooth muscle. Eur J Pharmacol. 1985;111(2):227-233.