Pregnanediol-3-glucuronide (PDG) is the primary urinary metabolite of the steroid hormone progesterone. [1] Levels of PDG in the urine correlate to levels of progesterone measured in the serum.[1] [2] Analysis of urinary PDG has been used to detect ovulatory and anovulatory menstrual cycles in women as well as to assess the fertility of ovulatory cycles.[3] [4]
Reference:
[1]. O'Connor, K.A., Brindle, E., Holman, D.J., et al. Urinary estrone conjugate and pregnanediol 3-glucuronide enzyme immunoassays for population research. Clin. Chem. 49(7), 1139-1148 (2003).
[2]. Munro, C.J., Stabenfeldt, G.H., Cragun, J.R., et al. Relationship of serum estradiol and progesterone concentrations to the excretion profiles of their major urinary metabolites as measured by enzyme immunoassay and radioimmunoassay. Clin. Chem. 37(6), 838-844 (1991).
[3]. Kassam, A., Overstreet, J.W., Snow-Harter, C., et al. Identification of anovulation and transient luteal function using a urinary pregnanediol-3-glucuronide ratio algorithm. Environ. Health Perspect. 104(4), 408-413 (1996).
[4]. Blackwell, L.F., Cooke, D.G., and Brown, S. The use of estrone-3-glucuronide and pregnanediol-3-Glucuronide Excretion Rates to Navigate the Continuum of Ovarian Activity. Front. Public Health 6:153, (2018).