Resolvin D3 (Synonyms: RvD3) |
カタログ番号GC44817 |
レゾルビン D3 (RvD3) は、ドコサヘキサエン酸 (DHA) 由来のメディエーターです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 916888-47-6
Sample solution is provided at 25 µL, 10mM.
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid . [1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response. [2] Resolvin D3 (RvD3) is a DHA-derived product first identified in mouse inflammatory exudates.[3] It reduces neutrophil infiltration in vivo in both mouse peritonitis and dermal inflammation. [3] In addition to suppressing leukocyte migration, RvD3 enhances macrophage phagocytosis and efferocytosis [4]. Unlike other resolvins, RvD3 appears late in resolution in mouse peritonitis. [4] [5] Analytical and biological comparisons of synthetic RvD3 with endogenously derived RvD3 have confirmed its identity as matching the natural product. [6]
Reference:
[1]. Hong, S., Gronert, K., Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J. Biol. Chem. 278(17), 14677-14687 (2003).
[2]. Ariel, A., and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. TRENDS in Immunology 28(4), 176-183 (2007).
[3]. Serhan, C.N., Hong, S., Gronert, K., et al. Resolvins: A family of bioactive products of ω-3 fatty acid transformation circuits by aspirin treatment that counter proinflammation signals. J. Exp. Med. 196(8), 1025-1037 (2002).
[4]. Dalli, J., Winkler, J.W., Colas, R.A., et al. Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents. Chem. Biol. 20(2), 188-201 (2015).
[5]. Serhan, C.N. Novel pro-resolving lipid mediators in inflammation are leads for resolution physiology. Nature 510(7503), 92-101 (2014).
[6]. Serhan, C. . (2007).
Cas No. | 916888-47-6 | SDF | |
同義語 | RvD3 | ||
Chemical Name | 4S,11R,17S-trihydroxy-5Z,7E,9E,13Z,15E,19Z-docosahexaenoic acid | ||
Canonical SMILES | O[C@@H](CCC(O)=O)/C=C\C=C\C=C\[C@H](O)C/C=C\C=C\[C@@H](O)C/C=C\CC | ||
Formula | C22H32O5 | M.Wt | 376.5 |
溶解度 | 50 mg/ml in DMF, 50 mg/ml Ethanol | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
1 mM | 2.656 mL | 13.2802 mL | 26.5604 mL |
5 mM | 0.5312 mL | 2.656 mL | 5.3121 mL |
10 mM | 0.2656 mL | 1.328 mL | 2.656 mL |
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Quality Control & SDS
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- Purity: >95.00%
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Average Rating: 5
(Based on Reviews and 3 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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