SB 200646 (Synonyms: SB 200646A) |
| カタログ番号GC25898 |
SB 200646（SB 200646A）は、50倍の選択性を持つ5-HT2B / 2C受容体に対する強力で選択的な経口活性拮抗剤であり、5-HT2A受容体に対して作用しません。ラット5-HT2C受容体、ラット5-HT2B受容体およびラット5-HT2A受容体のpKi値はそれぞれ6.9、7.5および5.2です。 SB 200646は生理学的および抗不安効果を有します。
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Cas No.: 143797-63-1
Sample solution is provided at 25 µL, 10mM.
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SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.
[1] Kennett GA, et al. Br J Pharmacol. 1994 Mar;111(3):797-802.
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