SBI-0087702 promots the cytoplasmic localization of ATF2 in melanoma cells. SBI-0087702-induced translocation of ATF2 to the mitochondria results in increased apoptosis due to loss of mitochondrial membrane integrity. SBI-0087702 also inhibits growth and motility of melanoma cells. SBI-0087702 was shown to inhibit ATF2 phosphorylation on Thr52 by PKCε [1].
References:
[1]. Tal Varsano, et al. Inhibition of Melanoma Growth by Small Molecules that Promote the Mitochondrial Localization of ATF2. Clin Cancer Res. 2013 May 15;19(10):2710-22.
References:
[1]. Tal Varsano, et al. Inhibition of Melanoma Growth by Small Molecules that Promote the Mitochondrial Localization of ATF2. Clin Cancer Res. 2013 May 15;19(10):2710-22.