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ST45177901

カタログ番号GC79216 Copy One-Click Copy Product Info

ST45177901 is a CC chemokine receptor 4 ( CCR4 ) antagonist.

Products are for research use only. Not for human use. We do not sell to patients.

ST45177901 化学構造

Cas No.: 618865-88-6

サイズ 価格 在庫数 個数
1mg
$219.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.



Description of ST45177901

ST45177901 is a CC chemokine receptor 4 ( CCR4 ) antagonist. The combination of ST45177901 and Sorafenib effectively inhibits the chemotaxis of Treg cells via the CCL22/CCL17-CCR4 signaling pathway, thereby significantly suppressing the growth and metastasis of tumor cells. ST45177901 is applicable to liver cancer research [1].

In Vivo, ST45177901 exhibits effects similar to those of C-021 (C-021, when combined with Sorafenib, effectively inhibits hepatocellular carcinoma growth) in mice[1].

References:
[1]. Yang, et al. Application of sorafenib combined with CCR4 antagonist for restraining cancer growth and transfer. CN106421796A. China. 2016-11-02.

Chemical Properties of ST45177901

Cas No. 618865-88-6 SDF
Formula C26H16ClN3O4S3 M.Wt 566.07
溶解度 Storage Store at -20°C
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of ST45177901

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1 mg 5 mg 10 mg
1 mM 1.7666 mL 8.8328 mL 17.6657 mL
5 mM 353.3 μL 1.7666 mL 3.5331 mL
10 mM 176.7 μL 883.3 μL 1.7666 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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