TAT-Gap19 |
| カタログ番号GC50390 |
Cx 模倣ペプチドである TAT-Gap19 は、特定のコネキシン 43 ヘミチャネル (Cx43 HC) 阻害剤です。
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Cas No.: 1507930-54-2
Sample solution is provided at 25 µL, 10mM.
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Cx43 hemichannel blocker (IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19 . Active in vivo. Brain penetrant.
Abudara et al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front.Cell.Neurosci. 8 1 PMID:25374505 |Freitas-Andrade and Naus (2016) Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1. Neuroscience. 323 207 PMID:25913636
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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