Theasinensin C is an orally effective renin inhibitor and gut microbiota modulator, with an IC50 of 40.21 μM against renin activity. Theasinensin C selectively enriches Akkermansia muciniphila in the gut microbiota, enhances the Akkermansia muciniphila -mediated hydrolysis of the PTS domain of mucin, drives the accumulation of luminal glutamine and serine, and regulates the gut-kidney-liver glutamine/serine metabolic signaling pathway to promote creatine biosynthesis. Theasinensin C improves cognitive function, reduces pro-inflammatory cytokines, alleviates neuropathological changes and restores intestinal barrier integrity. Theasinensin C can be used in research related to hypertension and neuroinflammation induced by high-fructose diet [1] [2].
In Vivo, Theasinensin C (150 mg/kg/day; oral gavage; daily; 8 weeks) mitigates HFrD-induced neuroinflammation in male C57BL/6J mice by improving cognitive function, reducing systemic and central inflammatory markers, restoring intestinal barrier integrity, and remodeling gut microbiota to enrich beneficial taxa like Akkermansia muciniphila[3]. Theasinensin C (150 mg/kg/day; oral gavage; daily; 8 weeks) attenuates HFrD-induced neuroinflammation in antibiotic-pretreated germ-free male C57BL/6J mice, with improvements in cognitive function and reduction of central inflammatory markers, though efficacy is enhanced when combined with Akkermansia muciniphila-derived metabolites[3].
In Vitro, Theasinensin C (48 h) enhances Akkermansia muciniphila XJ 240720-mediated degradation of the mucin PTS domain, resulting in a significant increase in luminal L-glutamine and L-serine levels[3].
References:
[1]. Li F, et al. Tea polyphenols as novel and potent inhibitory substances against renin activity. J Agric Food Chem. 2013;61(40):9697-9704.
[2]. Ji W, et al. Theasinensin C Mitigates HFrD-Induced Neuroinflammation by Enriching Akkermansia muciniphila and Orchestrating a Gln/Ser-Centered Multiorgan Metabolic Relay to Drive Creatine Biosynthesis. J Agric Food Chem. 2026 Apr 1;74(12):10281-10301.
In Vivo, Theasinensin C (150 mg/kg/day; oral gavage; daily; 8 weeks) mitigates HFrD-induced neuroinflammation in male C57BL/6J mice by improving cognitive function, reducing systemic and central inflammatory markers, restoring intestinal barrier integrity, and remodeling gut microbiota to enrich beneficial taxa like Akkermansia muciniphila[3]. Theasinensin C (150 mg/kg/day; oral gavage; daily; 8 weeks) attenuates HFrD-induced neuroinflammation in antibiotic-pretreated germ-free male C57BL/6J mice, with improvements in cognitive function and reduction of central inflammatory markers, though efficacy is enhanced when combined with Akkermansia muciniphila-derived metabolites[3].
In Vitro, Theasinensin C (48 h) enhances Akkermansia muciniphila XJ 240720-mediated degradation of the mucin PTS domain, resulting in a significant increase in luminal L-glutamine and L-serine levels[3].
References:
[1]. Li F, et al. Tea polyphenols as novel and potent inhibitory substances against renin activity. J Agric Food Chem. 2013;61(40):9697-9704.
[2]. Ji W, et al. Theasinensin C Mitigates HFrD-Induced Neuroinflammation by Enriching Akkermansia muciniphila and Orchestrating a Gln/Ser-Centered Multiorgan Metabolic Relay to Drive Creatine Biosynthesis. J Agric Food Chem. 2026 Apr 1;74(12):10281-10301.