VU0487836 |
カタログ番号GC79363
One-Click Copy Product Info
|
VU0487836 is a selective cyclooxygenase-1 ( COX-1 ) inhibitor with an IC50 of 0.36 μM against ovine-derived COX-1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1632301-78-0
Sample solution is provided at 25 µL, 10mM.
_1-3.$$$39978408@51.jpg');)
_1-9.$$$38538795@65.jpg');)
_1-9.$$$39112701@51.jpg');)
_1-7.$$$37316672@70.jpg');)
_366-372.$$$36198801@70.jpg');)
.$$$38565142@65.jpg');)
_1867-1883.$$$33248023@67.jpg');)
_eads6055.$$$39977546@45.jpg');)
_eadm9805.$$$40080571@45.jpg');)
_eadj3020.$$$39666821@45.jpg');)
_1-20.$$$39757301@28.jpg');)
_1-24.$$$38898113@28.jpg');)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
_1-19.$$$37460805@44.jpg');)
_1291-1307.$$$34518654@46.jpg');)
In Vitro, VU0487836 (compound 27) potently and selectively inhibits purified ovine COX-1 with an IC50 of 0.36 μM, while it shows no inhibitory activity against purified murine COX-2 (IC50 >25 μM)[1]. VU0487836 potently and selectively inhibits COX-1 in human ovarian cancer cell line OVCAR3 with an IC50 of 0.18 μM, while it shows no inhibitory activity against COX-2 in human 1483 head and neck squamous cell carcinoma cells (IC50 >5 μM)[1].
References:
[1]. Uddin MJ, et al. Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors. ACS Med Chem Lett. 2014 Oct 12;5(11):1254-8.
| Cas No. | 1632301-78-0 | SDF | |
| Formula | C17H13FO3 | M.Wt | 284.29 |
| 溶解度 | DMSO: 50 mg/mL (175.88 mM; Need ultrasonic) | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.5175 mL | 17.5877 mL | 35.1753 mL |
| 5 mM | 703.5 μL | 3.5175 mL | 7.0351 mL |
| 10 mM | 351.8 μL | 1.7588 mL | 3.5175 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)