GLPBio

JS11

Catalog No.: GC73468Purity:>99.00%
JS11 is an inhibitor for natriuretic polypeptide receptor 1 (Npr1) with an IC50 of 1.9 μM for hNpr1.

Products are for research use only. Not for human use. We do not sell to patients.


JS11
Cas No.: 1394592-04-1
5 mgIn Stock
$140.00
1
10 mgIn Stock
$223.00
1
25 mgIn Stock
$446.00
1

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    Cell Research
    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

Description

JS11 is an inhibitor for natriuretic polypeptide receptor 1 (Npr1) with an IC50 of 1.9 μM for hNpr1. JS11 ameliorates the pruritus in mouse models.

References:
[1]. Hoon MA, et al., Compositions and methods for the inhibition of pruritus. WO2019090039.

Product Documents

Purity:>99.00%Appearance:A solid

Chemical Properties

CAS No.
1394592-04-1
Molecular Formula
C23H28N4O3
Molecular Weight
408.49
Solubility
DMSO : 50 mg/mL (122.40 mM; ultrasonic and warming and heat to 60°C)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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