GLPBio

KF-52

Catalog No.: GC83335Purity:>98.50%
COASDSData Sheet
KF-52 is a phosphofructokinase-1 ( PFK1 ) inhibitor with an IC50 value of 2.1 μM.

Products are for research use only. Not for human use. We do not sell to patients.

KF-52
Cas No.: 3104612-74-7
1mgIn Stock
$259.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    Nature
    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    387(6734) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

KF-52 is a phosphofructokinase-1 ( PFK1 ) inhibitor with an IC50 value of 2.1 μM. KF-52 significantly increases the ratio of oxygen consumption rate (OCR) to extracellular acidification rate (ECAR). KF-52 is applicable to research related to mitochondrial dysfunction [1].

In Vitro, KF-52 (Compound 1c) inhibits purified phosphofructokinase-1 (PFK1) with an IC50 of 2.1 μM[1]. KF-52 (0-60 μM) increases the OCR/ECAR ratio in HeLa cells[1].

References:
[1]. Kakehi R, et al. Asymmetric Synthesis, Structure Determination, and Biologic Evaluation of Isomers of TLAM as PFK1 Inhibitors. ACS Med Chem Lett. 2024;16(1):59-63. Published 2024 Dec 4.

Product Documents

Purity:>98.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
3104612-74-7
Molecular Formula
C21H19F3N2O3
Molecular Weight
404.38
Solubility
DMSO: 100 mg/mL (247.29 mM; Need ultrasonic)
Storage
Store at -20°C
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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