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Home >> Proteins >> Enzymes >> Phosphatase

Phosphatase

Products for  Phosphatase

  1. Cat.No. Product Name Information
  2. GC74184 (R)-Azasetron besylate

    SENS-401

     (R)-Azasetron besylate (SENS-401) is an orally active calcineurin inhibitor. (R)-Azasetron besylate Chemical Structure
  3. GC41774 1,2,3-Trimyristoyl-rac-glycerol

    Glycerol Tritetradecanoate, Myristic Acid Triglyceride, NSC 4062, TG(14:0/14:0/14:0), Tritetradecanoyl Glycerol

     1,2,3-Trimyristoyl-rac-glycerol, an active molluscicidal component ofMyristica fragransHoutt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue ofLymnaea acuminata. 1,2,3-Trimyristoyl-rac-glycerol Chemical Structure
  4. GC25005 1-Naphthyl phosphate potassium salt

    α-Naphthyl acid phosphate monopotassium salt

     1-Naphthyl phosphate potassium salt (α-Naphthyl acid phosphate monopotassium salt) is a non-specific phosphatase inhibitor which acts on acid, alkaline, and protein phosphatases. 1-Naphthyl phosphate potassium salt Chemical Structure
  5. GC72952 1E7-03 1E7-03, a low MW tetradroquinoline derivative targeting protein phosphatase-1, can inhibit HIV-1 transcription. 1E7-03 Chemical Structure
  6. GC60019 3,5-Difluoro-L-tyrosine 3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine Chemical Structure
  7. GC65394 7-BIA 7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM. 7-BIA Chemical Structure
  8. GC63921 ABBV-CLS-484 ABBV-CLS-484 is a potent PTPN1 or PTPN2 inhibitor with a sub-nanomolar activity. ABBV-CLS-484 Chemical Structure
  9. GC71420 ALP/Carbonic anhydrase-IN-1 ALP/Carbonic anhydrase-IN-1 (Compound 1e) is a dual carbonic anhydrase (CA) and alkaline phosphatase (ALP) inhibitor. ALP/Carbonic anhydrase-IN-1 Chemical Structure
  10. GC65098 ARL67156 triethylamine

    FPL 67156 triethylamine

     ARL67156 (FPL 67156) triethylamine is a selective ecto-ATPase inhibitor. ARL67156 triethylamine Chemical Structure
  11. GC65097 ARL67156 trisodium hydrate

    FPL 67156 trisodium hydrate

    ARL67156 (FPL 67156) trisodium hydrate is a selective ecto-ATPase inhibitor.

     ARL67156 trisodium hydrate Chemical Structure
  12. GC60600 ARL67156 trisodium salt hydrate ARL67156 trisodium salt hydrate Chemical Structure
  13. GC46093 Azadirachtin B

    Deacetylazadirachtinol, 3-Tigloylazadirachtol

     An azadirachtin with diverse biological activities Azadirachtin B Chemical Structure
  14. GC65025 BCI hydrochloride

    (E)-BCI hydrochloride

     BCI ((E)-BCI) hydrochloride is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI hydrochloride Chemical Structure
  15. GC60647 Bis(maltolato)oxovanadium(IV) Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases) inhibitor. Bis(maltolato)oxovanadium(IV) Chemical Structure
  16. GC72918 BN-82685

    IRC-083065

     BN-82685 is a a quinone-based CDC25 inhibitor with IC50 of 201 nM, 117 nM, 109 nM, 160 nM, 249 nM, for CDC25C, CDC25C-cat, CDC25A, CDC25B2, CDC25B3, respectively. BN-82685 Chemical Structure
  17. GC63788 BN82002 hydrochloride BN82002 hydrochloride is a potent, selective and irreversible inhibitor of CDC25 phosphatase family. BN82002 hydrochloride inhibits CDC25A, CDC25B2, CDC25B3, CDC25C CDC25A, and 25C-cat with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 ?M, respectively. BN82002 hydrochloride displays ~20-fold greater selectivity over CD45 tyrosine phosphatase. BN82002 hydrochloride Chemical Structure
  18. GC42969 bpV(phen) (potassium hydrate)

    Bisperoxovanadium(phen), Potassium Bisperoxo(1,10phenanthroline) oxovanadate (V)

     bpV(phen) (potassium hydrate), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) (potassium hydrate) Chemical Structure
  19. GC64161 Calcium glycerophosphate Calcium glycerophosphate is an inhibitor of intestinal alkaline phosphatase F3. Calcium glycerophosphate Chemical Structure
  20. GC62892 CDC25B-IN-2 CDC25B-IN-2 is a potent cdc25B inhibitor. CDC25B-IN-2 Chemical Structure
  21. GC60706 Chrysophanol triglucoside Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia, inhibits protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase with IC50s of 80.17 and 197.06 ?M, respectively. Chrysophanol triglucoside Chemical Structure
  22. GC20061 ClAP (Alkaline Phosphatase, Calf intestinal)

    ClAP (Alkaline Phosphatase, Calf intestinal) is a membrane-bound glycoprotein that hydrolyzes a broad range of monophosphate esters at alkaline pH.

     ClAP (Alkaline Phosphatase, Calf intestinal) Chemical Structure
  23. GC62909 CPT-157633 CPT-157633, a difluoro-phosphonomethyl phenylalanine derivative, and is a PTP1B inhibitor. CPT-157633 Chemical Structure
  24. GC39295 DJ001 DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase-σ (PTPσ) inhibitor with an IC50 of 1.43 μM. DJ001 Chemical Structure
  25. GC62943 DPM-1001 trihydrochloride DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM. DPM-1001 trihydrochloride Chemical Structure
  26. GC65260 EDP-305 EDP-305 is an orally active, potent and selective farnesoid X receptor (FXR) agonist, with EC50 values of 34 nM (chimeric FXR in CHO cells) and 8 nM (full-length FXR in HEK cells). EDP-305 Chemical Structure
  27. GC69090 EWP 815

    EWP 815 is a disulfide analogue and an effective inhibitor of Ins(1,4)P2 phosphatase and Ins(1,4,5)P3 5-phosphatase. It also participates in inhibiting the activity of dopamine beta-hydroxylase in vivo.

     EWP 815 Chemical Structure
  28. GC59040 FAM alkyne, 5-isomer FAM alkyne, 5-isomer is a high selective and sensitive fluorescent biosensor for alkaline phosphatase (ALP). FAM alkyne, 5-isomer Chemical Structure
  29. GC46147 Fenvalerate A pyrethroid ester insecticide and acaricide Fenvalerate Chemical Structure
  30. GC63327 Fenvalerate-d5 Fenvalerate-d5 Chemical Structure
  31. GC64376 GDC-1971 GDC-1971 (compound 199) is a SHP2 inhibitor. GDC-1971 Chemical Structure
  32. GC67938 Guaiacin Guaiacin Chemical Structure
  33. GC69231 HKB99

    HKB99 is a conformational inhibitor of phosphoglycerate mutase 1 (PGAM1), which is a glycolytic enzyme. HKB99 inhibits the formation of invasive pseudopodia and increases the level of plasminogen activator inhibitor-2 (PAI-2). It also increases oxidative stress, activates JNK/c-Jun, and inhibits AKT and ERK. HKB99 can be used for research on non-small cell lung cancer (NSCLC).

     HKB99 Chemical Structure
  34. GC62345 IACS-13909 IACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM. IACS-13909 is more selective for SHP2 than other phosphatases (including SHP1). IACS-13909 has antitumor activities and suppresses MAPK pathway signaling in receptor tyrosine kinases (RTK)-dependent cancers. IACS-13909 Chemical Structure
  35. GC62677 Icerguastat

    Sephin1; IFB-088

     Icerguastat (Sephin1), a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat Chemical Structure
  36. GC69315 JMS-053

    JMS-053 is an effective, selective, and reversible inhibitor of PTP4A. It inhibits PTP4A1, PTP4A2, PTP4A3, CDC25B and DUSP3 with IC50 values of 29.1 nM, 48.0 nM, 34.7 nM, 92.6 nM and 207.6 nM respectively. JMS-053 can inhibit cancer cell migration and spheroid growth while reducing the growth of ovarian tumors in vivo.

     JMS-053 Chemical Structure
  37. GC69323 JUN-1111

    JUN-1111 is an irreversible selective inhibitor of Cdc25 phosphatase, with IC50 values of 0.38, 1.8, 0.66, 28 and 37 μM for Cdc25A, Cdc25B, Cdc25C, VHR and PTP1B respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases and reduces the expression of phosphoCdk1.

     JUN-1111 Chemical Structure
  38. GC44008 KLH45 KLH45 is an inhibitor of the phospholipase DDHD domain containing 2 (DDHD2; IC50 = 1.3 nM). KLH45 Chemical Structure
  39. GC70408 KLH45b KLH45b is an inhibitor of DDHD2 (DDHD domain containing 2). KLH45b Chemical Structure
  40. GC61578 L-690330 hydrate L-690330 hydrate is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 hydrate Chemical Structure
  41. GC19511 L-Ascorbic Acid 2-phosphate (magnesium salt)

    AA2P, Ascorbyl PM, Phospitan C

     L-Ascorbic Acid 2-phosphate (magnesium salt) (AA2P) is a stable VC(vitamin C) derivative. L-Ascorbic Acid 2-phosphate (magnesium salt) Chemical Structure
  42. GC64338 LYP-IN-1 LYP-IN-1 is a potent, selective and specific LYP inhibitor with a Ki and an IC50 of 110 nM and 0.259 μM, respectively. LYP-IN-1 Chemical Structure
  43. GC73595 LYP-IN-3 LYP-IN-3 (compound D34) is a selective inhibitor of Lymphoid-tyrosine phosphatase (LYP) (Ki=0.93 μM), and regulates T-cell receptor (TCR) signaling pathway in tumor progress. LYP-IN-3 Chemical Structure
  44. GC73020 M5N36 M5N36 is a potent and selective Cdc25C inhibitor with IC50 values of 0.15, 0.19, 0.06 µM for Cdc25A, Cdc25B, Cdc25C, respectively. M5N36 Chemical Structure
  45. GC70326 ML 400 ML 400 is a potent and selective LMPTP inhibitor with an IC50 value of 1680 nM. ML 400 Chemical Structure
  46. GC67798 MLS-0437605 MLS-0437605 Chemical Structure
  47. GC61408 MLS000544460 MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a Kd of 2.0 μM and an IC50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity. MLS000544460 Chemical Structure
  48. GC64031 MP07-66 MP07-66, a FTY720 analogue, is devoid of immunosuppressive effects and shows promising antitumor effects in chronic lymphocytic leukemia by disruption of the SET-PP2A complex leading to PP2A reactivation. MP07-66 Chemical Structure
  49. GC64030 MY10 MY10 is a potent and orally active receptor protein tyrosine phosphatase (RPTPβ/ζ) inhibitor. MY10 Chemical Structure
  50. GC69515 MY33-3

    MY33-3 is an effective and selective inhibitor of protein tyrosine phosphatase RPTPβ/ζ, with an IC50 value of ~0.1 μM. MY33-3 also inhibits PTP-1B (IC50 ~0.7 μM). MY33-3 can reduce ethanol consumption and alleviate neuroinflammation and cognitive dysfunction caused by Sevoflurane.

     MY33-3 Chemical Structure
  51. GC64605 MY33-3 hydrochloride MY33-3 hydrochloride is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM. MY33-3 hydrochloride Chemical Structure
  52. GC65157 Naphthol AS-BR Naphthol AS-BR is a substrate for the histochemical demonstration of acid and alkaline phosphatase. Naphthol AS-BR Chemical Structure
  53. GC61621 NAZ2329 NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC50=7.5 ?M for hPTPRZ1) and PTPRG (IC50=4.8 ?M for hPTPRG) over other PTPs. NAZ2329 binds to the active D1 domain and more potently inhibits PTPRZ-D1 fragment (IC50 of 1.1 ?M) than the whole intracellular (D1?+?D2) fragment (IC50 of 7.5 ?M). NAZ2329 can effectively inhibit tumor growth of the glioblastoma cells and suppress stem cell-like properties. NAZ2329 Chemical Structure
  54. GC61403 NCGC00249987 NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of Eya2 inhibitor with IC50s of 3 μM and 6.9 μM for Eya2 ED and MBP-Eya2 FL. NCGC00249987 specifically targets migration, invadopodia formation, and invasion of lung cancer cells. NCGC00249987 Chemical Structure
  55. GC62286 NCGC00378430 NCGC00378430 is a potent inhibitor of the SIX1/EYA2 protein-protein interaction. NCGC00378430 Chemical Structure
  56. GC65542 NSC-87877 disodium NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26). NSC-87877 disodium Chemical Structure
  57. GC71216 PFKFB3-IN-2 PFKFB3-IN-2 is a 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) inhibitor. PFKFB3-IN-2 Chemical Structure
  58. GC73072 Phosphoglycolic acid lithium Phosphoglycolic acid (lithium) is a competitive inhibitor of phosphoglycerate mutase (PGAM)-B, an enzyme of the glycolytic pathway. Phosphoglycolic acid lithium Chemical Structure
  59. GC61609 PHPS1 sodium PHPS1 sodium is a potent and selective Shp2 inhibitor with Kis of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively. PHPS1 sodium Chemical Structure
  60. GC70779 Pimecrolimus hydrate Pimecrolimus hydrate (SDZ-ASM 981 hydrate) is a potent, nonsteroid and orally active calcineurin inhibitor. Pimecrolimus hydrate Chemical Structure
  61. GC73572 PP5-IN-1 PP5-IN-1 (Compound P053) is a competitive inhibitor of Serine/threonine protein phosphatase-5 (PP5) that binds to its catalytic domain and causes apoptosis in renal cancer. PP5-IN-1 Chemical Structure
  62. GC69736 PRL-3 Inhibitor 2

    PRL-3 Inhibitor 2 (compound 2) is an effective inhibitor of PRL-3, with an IC50 value of 28.1 μM.

     PRL-3 Inhibitor 2 Chemical Structure
  63. GC39066 Prunin

    Naringenin 7-O-β-D-glucopyranoside, Naringenin 7-O-glucoside, NSC 135064

     A flavonoid glycoside with diverse biological activities Prunin Chemical Structure
  64. GC64556 PTP1B-IN-15 PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). PTP1B-IN-15 Chemical Structure
  65. GC63705 PTP1B-IN-3 diammonium PTP1B-IN-3 diammonium is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP. PTP1B-IN-3 diammonium Chemical Structure
  66. GC73467 PTPN2/1-IN-2 PTPN2/1-IN-2 is a PTPN2/1 antagonist that can be used in various tumor research. PTPN2/1-IN-2 Chemical Structure
  67. GC62687 Razuprotafib

    AKB-9778

     Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM. Razuprotafib Chemical Structure
  68. GC63487 RMC-4630

    SHP2-IN-7

     RMC-4630 (SHP2-IN-7) is an SHP2 inhibitor extracted from patent WO2018013597. RMC-4630 Chemical Structure
  69. GC61524 SC-43 SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects. SC-43 Chemical Structure
  70. GC65308 SHIP2-IN-1 SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 ?M. SHIP2-IN-1 Chemical Structure
  71. GC25930 SHP099 HCl SHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1. SHP099 HCl Chemical Structure
  72. GC62570 SHP2-IN-6 hydrochloride SHP2-IN-6 hydrochloride is a potent SHP2 inhibitor with an IC50 of 25.8 nM. SHP2-IN-6 hydrochloride is extracted from patent WO2017211303A1, compound 7. SHP2-IN-6 hydrochloride Chemical Structure
  73. GC63190 SHP389 SHP389 is an allosteric SHP2 inhibitor, with an IC50 of 36 nM for both SHP2 and p-ERK. SHP389 Chemical Structure
  74. GC65533 SHP394 SHP394 is an orally active, selective and allosteric inhibitor of SHP2, with an IC50 of 23 nM. SHP394 Chemical Structure
  75. GC60337 SHP836 SHP836 is a SHP2 allosteric inhibitor, with an IC50 of 12 μM for the full length SHP2. SHP836 Chemical Structure
  76. GC69932 SPAA-52

    SPAA-52 is a low molecular weight protein tyrosine phosphatase (LMW-PTP) inhibitor with oral activity, competitive and reversible properties (IC50=4 nM, Ki=1.2 nM). SPAA-52 can be used for research on diabetes.

     SPAA-52 Chemical Structure
  77. GC62191 TD52 TD52, an Erlotinib derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p-EGFR inhibition and has potent anti-cancer activity. TD52 Chemical Structure
  78. GC64936 TD52 dihydrochloride TD52 dihydrochloride, an Erlotinib derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 dihydrochloride indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 dihydrochloride has less p-EGFR inhibition and has potent anti-cancer activity. TD52 dihydrochloride Chemical Structure
  79. GC60364 Thienopyridone Thienopyridone is a potent and selective phosphatase of regenerating liver (PRL) phosphatase inhibitor with IC50s of 173 nM, 277 nM and 128 nM for PRL-1, PRL-2, and PRL-3, respectively. Thienopyridone shows minimal effects on other phosphatases. Thienopyridone induces p130Cas cleavage and apoptosis and has anticancer effects. Thienopyridone Chemical Structure
  80. GC61347 TRC-766 TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 Chemical Structure
  81. GC26007 Tridecafluorohexane-1-sulfonic acid potassium salt

    Potassium perfluorohexanesulfonate

     Tridecafluorohexane-1-sulfonic acid potassium salt is a perfluorinated anionic surfactant, mainly used as a chrome mist suppressant in electroplating, a wetting agent, and an additive in fluoroprotein foam fire extinguishing agents. Tridecafluorohexane-1-sulfonic acid potassium salt Chemical Structure
  82. GC70095 Uralenol

    Uralenol is a natural PTP1B inhibitor (IC50=21.5 μM) derived from Broussonetia papyrifera. In many cellular and biochemical studies, PTP1B has been shown to play a major role in the dephosphorylation of insulin receptors.

     Uralenol Chemical Structure
  83. GC31769 Voclosporin (ISAtx-247)

    ISAtx-247

     Voclosporin (ISAtx-247) is an orally active calcineurin inhibitor. Voclosporin blocks IL-2 expression and T cell-mediated immune responses by inhibiting calcineurin, while stabilizing renal podocytes to reduce kidney injury. Voclosporin (ISAtx-247) Chemical Structure
  84. GC18533 ZLDI-8

    Temiverine hydrochloride is a synthesized drug that is expected to have anticholinergic action.

    ZLDI-8 Chemical Structure

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