KP-2067 is a form of the CaSR agonist peptide. KP-2067 can result in dose-dependent activation of CaSR in HEK293T overexpressing hCaSR cell line, with an EC 50 of 18.4 μM. KP-2067 significantly reduces plasma parathyroid hormone in rat model [1].
References:
[1]. Alexander, S. T., et al., (2015). Critical Cysteine Residues in Both the Calcium-Sensing Receptor and the Allosteric Activator AMG 416 Underlie the Mechanism of Action. Molecular pharmacology, 88(5), 853-865.
References:
[1]. Alexander, S. T., et al., (2015). Critical Cysteine Residues in Both the Calcium-Sensing Receptor and the Allosteric Activator AMG 416 Underlie the Mechanism of Action. Molecular pharmacology, 88(5), 853-865.