GLPBio

CaSR

CASR (calcium sensing receptor) is a G-protein couple receptor which regulates the calcium homeostasis and involved in proliferation, differentiation and other hormonal secretion.

Products Related to CaSR(25)

  • GC12442 structure
    GC12442Strontium chloride
    CAS: 10476-85-4
    Purity: >99.00%

    Calcium sensing receptor (CaSR) agonist

  • GC16943 structure
    GC16943NPS-2143
    CAS: 284035-33-2
    Purity: >99.00%

    NPS-2143 is an orally active calcium-sensing receptor (CaSR) antagonist that induces an increase in cytosolic Ca 2+ concentration, with an IC 50 of 43nM. NPS-2143 stimulates the release of parathyroid hormone.

  • GC17697 structure
    GC17697Calhex 231 hydrochloride
    CAS: 652973-93-8
    Purity: >99.00%

    Calhex 231 hydrochloride is a negative allosteric modulator of the calcium-sensing receptor (CaSR), which can block the accumulation of inositol phosphates induced by Ca 2+ . Calhex 231 hydrochloride IC 50 value in HEK293 cells is 0.39μM. Calhex 231 hydrochloride is commonly used in the research of vascular-related diseases.

  • GC17700 structure
    GC17700R 568 hydrochloride
    CAS: 177172-49-5
    Purity: >98.00%

    R 568 hydrochloride is a kind of calcimimetic agent which can changed the structural conformation of the calcium-sensing receptor (CaSR) and stereo-selectively increased its sensitivity to extracellular Ca 2+ .

  • GA22389 structure
    GA22389H-Glu-Thr-OH
    CAS: 6875-80-5
    Purity: >99.00%

    H-Glu-Thr-OH, a dipeptide, formed by the connection of two amino acids-glutamic acid and threonine through a peptide bond, is usually found as a building block or fragment.

  • GC11819 structure
    GC11819Strontium Ranelate
    CAS: 135459-87-9
    Purity: >99.50%

    Calcium Channel activator

  • GC12240 structure
    GC12240NPS-2143 hydrochloride
    CAS: 324523-20-8
    Purity: >99.50%

    An orally-active CaSR antagonist

  • GC12620 structure
    GC12620Calindol (hydrochloride)
    CAS: 729610-18-8
    Purity: >98%

    activator of the calcium-sensing receptor (CaSR)

  • GC13518 structure
    GC13518Cinacalcet
    CAS: 226256-56-0
    Purity: >99.50%
  • GC16708 structure
    GC16708Cinacalcet HCl
    CAS: 364782-34-3
    Purity: >99.50%

    Cinacalcet HCl (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

  • GC17244 structure
    GC17244Calcium-Sensing Receptor Antagonists I
    CAS: 478963-79-0
    Purity: >99.50%
  • GC19973 structure
    GC19973Poly-D-lysine hydrobromide (M.W 70000~150000)
    CAS: 27964-99-4

    Poly-D-lysine hydrobromide (MW 70,000 ~ 150,000) is a cell non-specific attachment factor that is often used to promote the adhesion of cells to solid matrices.

  • GC19974 structure
    GC19974Poly-D-lysine hydrobromide (M.W 150000~300000)
    CAS: 27964-99-4
    Purity: >99.50%

    Poly-D-lysine hydrobromide (M.W 150000~300000) is a cell non-specific attachment factor that is often used to promote the adhesion of cells to solid matrices.

  • GC30095 structure
    GC30095SB-423562
    CAS: 351490-27-2
    Purity: >99.50%

    SB-423562 is a short-acting calcium-sensing receptor (CaR) antagonist.

  • GC30389 structure
    GC30389Evocalcet (KHK7580)
    CAS: 870964-67-3
    Purity: >99.00%

    Evocalcet (KHK7580) has an activating effect on calcium sensing receptor (CaSR) extracted from patent WO 2017061621 A1, compound A.

  • GC38147 structure
    GC38147Etelcalcetide hydrochloride
    CAS: 1334237-71-6
    Purity: >98.00%

    A peptide agonist of CaSR

  • GC38148 structure
    GC38148Etelcalcetide
    CAS: 1262780-97-1
    Purity: >98%

    Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR).

  • GC50365 structure
    GC50365AC 265347
    CAS: 1253901-26-6
    Purity: >99.00%

    Biased allosteric modulator of calcium-sensing receptor (CaSR)

  • GC63745 structure
    GC63745Cinacalcet-D3
    Purity: >98%
  • GC64905 structure
    GC64905(Rac)-Upacicalcet
    CAS: 2649575-19-7
    Purity: >95.00%

    (Rac)-Upacicalcet is the racemate of Upacicalcet.

  • GC64923 structure
    GC64923Upacicalcet sodium
    CAS: 2052969-18-1
    Purity: >98.00%

    Upacicalcet sodium is an intravenous calcimimetic agent.

  • GC69193 structure
    GC69193GSK3004774
    CAS: 2138814-32-9
    Purity: >98%

    GSK3004774 is an effective, non-absorbable CaSR agonist with pEC50 values of 7.3, 6.6 and 6.5 for human, mouse and rat CaSR respectively, and an EC50 value of 50 nM for human CaSR.

  • GC79197 structure
    GC79197Gamma-Glu-Abu acetate
    Purity: >99.50%

    Gamma-Glu-Abu acetate is a CaSR activator with an EC 50 of 0.21 μM (in HEK-293 cells).

  • GC79198 structure
    GC79198KP-2067
    CAS: 1262781-19-0
    Purity: >98%

    KP-2067 is a form of the CaSR agonist peptide.