5-((tert-Butyldimethylsilyl)oxy)pentanal is a PROTAC linker that can be used in the synthesis of PROTACs.
In Vitro, PROTACs contain two different ligands connected by a linker; one is a ligand for an E399 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
In Vitro, PROTACs contain two different ligands connected by a linker; one is a ligand for an E399 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.