AGN 193109-d7 is intended for use as an internal standard for the quantification of AGN 193109 by GC- or LC-MS. AGN 193109 is an antagonist of retinoic acid receptors (RARs).1 AGN 193109 decreases expression of cytokeratin K5-8, 13, 14, 16, 17, and 19 genes, markers of retinoid action in ECE16-1 cells, when co-administered with TTNPB but not when used alone. In vivo, AGN 193109 induces cleft palate or frontonasal dysplasia and eye malformations in fetuses of pregnant mice following a single oral dose of 1 mg/kg.2
1.Agarwal, C., Chandraratna, A.S., Johnson, A.L., et al.AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cellsJ. Biol. Chem.271(21)12209-12212(1996) 2.Kochhar, D.M., Jiang, H., Penner, J.D., et al.The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental eventsInt. J. Dev. Biol.42(4)601-608(1998)