Anti-Mouse CD3 Antibody (17A2) is an anti-mouse CD3 IgG2b antibody inhibitor derived from the host Rat. Anti-Mouse CD3 Antibody (17A2) enhances T-cell proliferation and activation and stimulate IFN-γ or IL-17 production in splenic T cells. Anti-Mouse CD3 Antibody (17A2) significantly suppresses mortality in Graft-versus-host disease (GVHD) mice models [1] [2].
In Vivo, Anti-Mouse CD3 Antibody (17A2) (100 or 400 μg, i.v., a single dose) depletes T cells in mice[2]. Anti-Mouse CD3 Antibody (17A2) (200 or 400 μg, i.v., 20 h after irradiation and 4 h before transplantation) significantly suppresses mortality in Graft-versus-host disease (GVHD) mice models [2].
In Vitro, Anti-Mouse CD3 Antibody (17A2) (1-1000 ng/mL, 96 h) enhances T-cell proliferation and activation and stimulate IFN-γ or IL-17 production in splenic pan-T cells[1]. Anti-Mouse CD3 Antibody (17A2) (1 μg/mL, 48 h) significantly elevates mRNA levels for these Th1 and IL-17 genes in splenic T cells[1]. Anti-Mouse CD3 Antibody (17A2) (48 h) significantly enhances IRBP (interphotoreceptor retinoid-binding protein)-stimulated production of IFN-γ in ocular cells[1].
References:
[1]. Sugita S, et al. Inhibition of T cell-mediated inflammation in uveitis by a novel anti-CD3 antibody. Arthritis Res Ther. 2017 Jul 25;19(1):176.
[2]. Mysliwietz J, et al. Antilymphocytic antibodies and marrow transplantation. XII. Suppression of graft-versus-host disease by T-cell-modulating and depleting antimouse CD3 antibody is most effective when preinjected in the marrow recipient. Blood. 1992 Nov 15;80(10):2661-7.
In Vivo, Anti-Mouse CD3 Antibody (17A2) (100 or 400 μg, i.v., a single dose) depletes T cells in mice[2]. Anti-Mouse CD3 Antibody (17A2) (200 or 400 μg, i.v., 20 h after irradiation and 4 h before transplantation) significantly suppresses mortality in Graft-versus-host disease (GVHD) mice models [2].
In Vitro, Anti-Mouse CD3 Antibody (17A2) (1-1000 ng/mL, 96 h) enhances T-cell proliferation and activation and stimulate IFN-γ or IL-17 production in splenic pan-T cells[1]. Anti-Mouse CD3 Antibody (17A2) (1 μg/mL, 48 h) significantly elevates mRNA levels for these Th1 and IL-17 genes in splenic T cells[1]. Anti-Mouse CD3 Antibody (17A2) (48 h) significantly enhances IRBP (interphotoreceptor retinoid-binding protein)-stimulated production of IFN-γ in ocular cells[1].
References:
[1]. Sugita S, et al. Inhibition of T cell-mediated inflammation in uveitis by a novel anti-CD3 antibody. Arthritis Res Ther. 2017 Jul 25;19(1):176.
[2]. Mysliwietz J, et al. Antilymphocytic antibodies and marrow transplantation. XII. Suppression of graft-versus-host disease by T-cell-modulating and depleting antimouse CD3 antibody is most effective when preinjected in the marrow recipient. Blood. 1992 Nov 15;80(10):2661-7.