Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) is an anti-mouse/rat/human CD47/IAP IgG1 monoclonal antibody. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can effectively block CD47 signaling and enhance macrophage phagocytic function. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can increase the infiltration of immune cells. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) may interfere with wound healing. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) can be used for researches on cancer and inflammation conditions such as breast cancer and intestinal mucosal repair [1] [2].
In Vivo, Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) (400 μg, i.p., single dose, 24 hours after the wound) significantly inhibits mucosal wound healing in male C57Bl/6J mice with a biopsy-based mucosal wound model[1]. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) (400 μg, intratumorally injection, once every 2 days, for 30 days) significantly inhibits tumor growth in FVB mice bearing MT1A2 tumors[2].
In Vitro, Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) (10 μg/mL, 24 h) significantly inhibits epithelial cell migration and wound closure[1]. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) (10-20 μg/mL, 2-4 h) significantly enhances the phagocytic activity of macrophages towards tumor cells[2].
References:
[1]. Reed M, et al. Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo. Nat Commun. 2019 Nov 1;10(1):5004.
[2]. Willingham SB, et al. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6662-7.
In Vivo, Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) (400 μg, i.p., single dose, 24 hours after the wound) significantly inhibits mucosal wound healing in male C57Bl/6J mice with a biopsy-based mucosal wound model[1]. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) (400 μg, intratumorally injection, once every 2 days, for 30 days) significantly inhibits tumor growth in FVB mice bearing MT1A2 tumors[2].
In Vitro, Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) (10 μg/mL, 24 h) significantly inhibits epithelial cell migration and wound closure[1]. Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410) (10-20 μg/mL, 2-4 h) significantly enhances the phagocytic activity of macrophages towards tumor cells[2].
References:
[1]. Reed M, et al. Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo. Nat Commun. 2019 Nov 1;10(1):5004.
[2]. Willingham SB, et al. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6662-7.