AZD-8529 |
| Catalog No.GC31097 |
AZD-8529는 EC50이 285nM인 mGluR2의 강력하고 고도로 선택적이고 경구 생체이용 가능한 양성 알로스테릭 조절제이며 mGluR1, 3, 4, 5, 6, 7에서 20-25M에서 양성 알로스테릭 조절제 반응을 나타내지 않습니다. , 및 8개의 하위 유형.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1092453-15-0
Sample solution is provided at 25 µL, 10mM.
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AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes. AZD8529 potentiates the effects of glutamate at mGluR2 with an EC50 of 195±62 nM[1].
AZD-8529 (0.3, 1 or 3 mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys. AZD-8529 (30 mg/kg) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats[1].
[1]. Justinova Z, et al. The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. Biol Psychiatry. 2015 Oct 1;78(7):452-62.
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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