Bisphenol F bis(2-chloro-1-propanol) ether (BFDGE·2HCl) is an androgen receptor antagonist with a human IC50 of 18 μM. Bisphenol F bis(2-chloro-1-propanol) ether binds to the androgen receptor. Bisphenol F bis(2-chloro-1-propanol) ether (BFDGE·2HCl) can be used for research on hormonal activity [1] [2].
In Vitro, Bisphenol F bis(2-chloro-1-propanol) ether (10 pM-10 μM M; 16-24 h) exhibits no androgen agonistic activity in AR-EcoScreen CHO-K1 cells[1]. Bisphenol F bis(2-chloro-1-propanol) ether (1 nM-100 μM; 16-24 h) acts as a potent androgen antagonist in AR-EcoScreen CHO-K1 cells, with an IC50 of 5.2×10-6 M for inhibiting DHT-induced luciferase activity, and shows no cell toxicity at active concentrations[1]. Bisphenol F bis(2-chloro-1-propanol) ether binds to human androgen receptor with an IC50 of 1.8×10-5 M, reducing specific testosterone binding in a concentration-dependent manner[1]. Bisphenol F bis(2-chloro-1-propanol) ether has negligible binding affinity for human estrogen receptor α, with less than 40% inhibition of specific 17β-estradiol binding at concentrations up to 1.9×10-4 M[1]. Bisphenol F bis(2-chloro-1-propanol) ether (100 nM-100 μM; 24 h) exhibits no estrogenic agonistic activity in MVLN cells when tested at concentrations[1]. Bisphenol F bis(2-chloro-1-propanol) ether (100 nM-100 μM) does not induce proliferation of estrogen-sensitive MCF-7 cells[1].
References:
[1]. Satoh K, et al. Study on anti-androgenic effects of bisphenol a diglycidyl ether (BADGE), bisphenol F diglycidyl ether (BFDGE) and their derivatives using cells stably transfected with human androgen receptor, AR-EcoScreen. Food Chem Toxicol. 2004;42(6):983-993.
[2]. Zhang HL, et al. Urinary exposure level of emerging chemicals in Chinese pregnant women and their associations with oxidative stress. Emerg. Contam. 2015 Jun;11(2):100502.
In Vitro, Bisphenol F bis(2-chloro-1-propanol) ether (10 pM-10 μM M; 16-24 h) exhibits no androgen agonistic activity in AR-EcoScreen CHO-K1 cells[1]. Bisphenol F bis(2-chloro-1-propanol) ether (1 nM-100 μM; 16-24 h) acts as a potent androgen antagonist in AR-EcoScreen CHO-K1 cells, with an IC50 of 5.2×10-6 M for inhibiting DHT-induced luciferase activity, and shows no cell toxicity at active concentrations[1]. Bisphenol F bis(2-chloro-1-propanol) ether binds to human androgen receptor with an IC50 of 1.8×10-5 M, reducing specific testosterone binding in a concentration-dependent manner[1]. Bisphenol F bis(2-chloro-1-propanol) ether has negligible binding affinity for human estrogen receptor α, with less than 40% inhibition of specific 17β-estradiol binding at concentrations up to 1.9×10-4 M[1]. Bisphenol F bis(2-chloro-1-propanol) ether (100 nM-100 μM; 24 h) exhibits no estrogenic agonistic activity in MVLN cells when tested at concentrations[1]. Bisphenol F bis(2-chloro-1-propanol) ether (100 nM-100 μM) does not induce proliferation of estrogen-sensitive MCF-7 cells[1].
References:
[1]. Satoh K, et al. Study on anti-androgenic effects of bisphenol a diglycidyl ether (BADGE), bisphenol F diglycidyl ether (BFDGE) and their derivatives using cells stably transfected with human androgen receptor, AR-EcoScreen. Food Chem Toxicol. 2004;42(6):983-993.
[2]. Zhang HL, et al. Urinary exposure level of emerging chemicals in Chinese pregnant women and their associations with oxidative stress. Emerg. Contam. 2015 Jun;11(2):100502.