CLP 257 |
| Catalog No.GC50127 |
CLP 257은 616 nM의 EC50을 갖는 선택적 K+-Cl- 공동수송체 KCC2 활성화제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1181081-71-9
Sample solution is provided at 25 µL, 10mM.
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Selective KCC2 K+-Cl- cotransporter activator (EC50 = 616 nM). Exhibits selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, as well as 55 other receptors. Enhances Cl- transport and increases KCC2 plasma membrane expression in spinal slices with reduced KCC2 function. Alleviates hypersensitivity in rats with peripheral nerve injury.
Gagnon et al (2013) Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat.Med. 19 1524 PMID:24097188
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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