Copper ionophore I is an efficient copper ion carrier. Copper ionophore I can regulate various intracellular copper levels to induce cuproptosis, such as 4T1 ( IC50 = 0.45 μM) and MDA-MB-231( IC50 = 1.21 μM) cells. Copper ionophore I can induce an increase in ROS and cause mitochondrial dysfunction. Copper ionophore I can reduce the expression of FDX1, DLAT, and LIAS proteins. Copper ionophore I can activate immune related pathways and promote T cell infiltration. Copper ionophore I can be used for cancer research [1].
References:
[1]. Yu L, et al. Rational design of copper ionophores for efficient induction of cuproptosis via simple n-alkyl modification. Eur J Med Chem. 2026 Jan 5;301:118257.
References:
[1]. Yu L, et al. Rational design of copper ionophores for efficient induction of cuproptosis via simple n-alkyl modification. Eur J Med Chem. 2026 Jan 5;301:118257.