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홈 >> Signaling Pathways >> Proteases >> Mitochondrial Metabolism

Mitochondrial Metabolism

Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. These carbon fuels feed into the TCA cycle in the mitochondrial matrix to generate the reducing equivalents NADH and FADH2, which deliver their electrons to the electron transport chain. Mitochondria are complex organelles that play an important role in many facets of cellular function, from metabolism to immune regulation and cell death. Mitochondria are actively involved in a wide variety of cellular processes and molecular interactions, such as calcium buffering, lipid flux, and intracellular signaling. It is increasingly recognized that mitochondrial dysfunction is a hallmark of many diseases such as obesity/diabetes, cancer, cardiovascular and neurodegenerative diseases. Mitochondrial metabolism is a key determinant of tumor progression by impacting on functions such as epithelial-to-mesenchymal transition. Mitochondrial metabolism and derived oncometabolites shape the epigenetic landscape to alter aggressiveness features of cancer cells. Changes in mitochondrial metabolism are relevant for the survival of tumors in response to therapy.

Targets for  Mitochondrial Metabolism

Products for  Mitochondrial Metabolism

  1. Cat.No. 상품명 정보
  2. GC40801 (±)9(10)-DiHOME (±)9(10)-DiHOME은 9,10-DiHOME의 라세미체입니다. (±)9(10)-DiHOME Chemical Structure
  3. GC14049 (-)-Epigallocatechin gallate (EGCG)

    다양한 생물학적 활동을 가진 페놀

     (-)-Epigallocatechin gallate (EGCG) Chemical Structure
  4. GC41721 (R)-α-Lipoic Acid (R)-α-Lipoic acid is the naturally occurring enantiomer of lipoic acid, a cyclic disulfide antioxidant. (R)-α-Lipoic Acid Chemical Structure
  5. GC18596 (±)-2-propyl-4-Pentenoic Acid (±)-2-프로필-4-펜텐산(4-en-VPA)은 발프로산의 주요 독성 대사산물입니다. (±)-2-propyl-4-Pentenoic Acid Chemical Structure
  6. GC19528 1,4-Benzoquinone A toxic metabolite of benzene 1,4-Benzoquinone Chemical Structure
  7. GC49872 10-Formyltetrahydrofolate (sodium salt) (technical grade) 10-Formyltetrahydrofolate (나트륨 염) (기술 등급)은 동화 작용에서 포르밀 그룹의 공여체로 작용하는 tetrahydrofolic acid의 한 형태입니다. 10-Formyltetrahydrofolate (sodium salt) (technical grade) Chemical Structure
  8. GC46451 16F16 A PDI inhibitor 16F16 Chemical Structure
  9. GC42193 2-Thenoyltrifluoroacetone 2-Thenoyltrifluoroacetone은 킬레이트제입니다. 2-Thenoyltrifluoroacetone Chemical Structure
  10. GC49849 3-Aminosalicylic Acid A salicylic acid derivative 3-Aminosalicylic Acid Chemical Structure
  11. GC42351 4-carboxy TEMPO 4-carboxy TEMPO is a nitroxide and spin label. 4-carboxy TEMPO Chemical Structure
  12. GC49722 4-CF3-TPP-DC An inert mitochondriotropic carrier 4-CF3-TPP-DC Chemical Structure
  13. GC41310 5-Octyl-α-ketoglutarate In addition to its role in the Krebs cycle, α-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes. 5-Octyl-α-ketoglutarate Chemical Structure
  14. GC46779 Acequinocyl A naphthoquinone acaricide Acequinocyl Chemical Structure
  15. GC42695 Acetoacetyl Coenzyme A (sodium salt hydrate)

    Acetoacetyl coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway.

     Acetoacetyl Coenzyme A (sodium salt hydrate) Chemical Structure
  16. GC46789 Acetyl-L-carnitine-d3 (chloride) An internal standard for the quantification of L-acetylcarnitine Acetyl-L-carnitine-d3 (chloride) Chemical Structure
  17. GC19021 Adjudin Adjudin은 우수한 미토콘드리아 억제 효과가 있는 광범위하게 연구된 남성 피임약입니다. Adjudin은 또한 강력한 Cl-채널 차단제입니다. Adjudin Chemical Structure
  18. GC42742 ADT-OH ADT-OH는 황화수소 방출 공여체입니다. ADT-OH는 FADD를 상향 조절하여 세포 사멸을 유도하고 생체 내에서 흑색종의 발달을 억제합니다. ADT-OH는 암 질환 연구의 잠재력을 가지고 있습니다. ADT-OH Chemical Structure
  19. GC46812 Aflatoxin G1-13C17 An internal standard for the quantification of aflatoxin G1 Aflatoxin G1-13C17 Chemical Structure
  20. GC35262 Afzelin Afzelin(Kaempferol-3-O-rhamnoside)은 Houttuynia cordata Thunberg에서 발견되는 플라보놀 배당체이며 항균 및 해열제, 해독제 제조 및 염증 치료에 널리 사용됩니다. Afzelin Chemical Structure
  21. GC63642 Agaric acid Agaric acid (Agaricic Acid)는 곰팡이 부족의 다양한 식물에서 얻습니다. Agaric acid Chemical Structure
  22. GC18437 Alternariol monomethyl ether Anthocleista djalonensis(Loganiaceae)의 뿌리에서 분리된 Alternariol monomethyl ether는 식물 종의 중요한 분류학적 표지자입니다. Alternariol monomethyl ether Chemical Structure
  23. GC18274 Amiprofos-methyl 아미프로포스-메틸(BAY-NTN 6867)은 인산 아미드 제초제입니다. Amiprofos-methyl Chemical Structure
  24. GC42818 Antimycin A1 Antimycin A1은 ubiquinol-cytochrome c oxidoreductase의 특정 전자 전달 억제제입니다. Antimycin A1은 HIF-1α 활성화 억제로 인한 VEGF 생성 감소를 통해 혈관 신생을 억제합니다. Antimycin A1 Chemical Structure
  25. GC18621 Antimycin A2 Antimycin A2 is an active component of the antimycin A antibiotic complex. Antimycin A2 Chemical Structure
  26. GC42820 Antimycin A4 Antimycin A4 is an active component of the antimycin A antibiotic complex that is more polar than antimycin A1, antimycin A2, and antimycin A3. Antimycin A4 Chemical Structure
  27. GC42821 AP219 AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. AP219 Chemical Structure
  28. GC42823 AP39 AP39는 트리페닐포스포늄 유도체화된 아네톨 디티올티온 및 미토콘드리아를 표적으로 하는 황화수소(H2S) 공여자입니다. AP39 Chemical Structure
  29. GC42846 Arachidonoyl-L-carnitine (chloride)

    Carnitine facilitates the transport of fatty acids into the mitochondria to be used in fatty acid metabolism.

     Arachidonoyl-L-carnitine (chloride) Chemical Structure
  30. GC46883 AS-2077715 An inhibitor of fungal complex III AS-2077715 Chemical Structure
  31. GC31432 Asp-AMS

    Asp-AMS는 아스파르틸아데닐산의 아날로그로, 아스파르틸-tRNA 합성효소 억제제이며 미토콘드리아 효소의 강력한 경쟁적 억제제입니다.

     Asp-AMS Chemical Structure
  32. GC42874 Aureothin Aureothin is a natural nitroaryl-substituted polyketide that exhibits antitumor, antifungal, and insecticidal activities. Aureothin Chemical Structure
  33. GC40677 Avenaciolide Avenaciolide는 Aspergillus avenaceus에서 발견되는 항진균성 비스-γ-락톤입니다. Avenaciolide Chemical Structure
  34. GC18580 B355252 페녹시 티오펜 설폰아미드 소분자인 B355252는 강력한 NGF 수용체 작용제입니다. B355252 Chemical Structure
  35. GC49901 BAY-179 BAY-179는 강력하고 선택적인 종 교차 반응성 복합체 I 억제제(IC50=79μM)입니다. BAY-179 Chemical Structure
  36. GC49403 Benzarone Benzarone(Fragivix)은 난모세포에서 IC50이 2.8μM인 강력한 인간 요산 수송체 1(hURAT1) 억제제입니다. Benzarone Chemical Structure
  37. GC49318 Benzovindiflupyr A fungicide Benzovindiflupyr Chemical Structure
  38. GC41252 BI-6C9 BI-6C9는 고도로 특이적인 BH3 상호작용 도메인(Bid) 억제제로 미토콘드리아 외막 전위(MOMP)와 미토콘드리아 분열을 방지하고 미토콘드리아 세포사멸 유도 인자(AIF) 방출과 뉴런의 카스파제-비의존적 세포 사멸로부터 세포를 보호합니다. 1]. BI-6C9 Chemical Structure
  39. GC52355 BimS BH3 (51-76) (human) (trifluoroacetate salt) A Bim-derived peptide BimS BH3 (51-76) (human) (trifluoroacetate salt) Chemical Structure
  40. GC18408 BML-278 BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 uM. BML-278 Chemical Structure
  41. GC46943 Boscalid A broad-spectrum carboxamide fungicide Boscalid Chemical Structure
  42. GC42978 Bromamphenicol Bromamphenicol is a dibrominated derivative of the antibiotic chloramphenicol. Bromamphenicol Chemical Structure
  43. GC43030 C16 dihydro Ceramide (d18:0/16:0)

    A bioactive sphingolipid

     C16 dihydro Ceramide (d18:0/16:0) Chemical Structure
  44. GC48425 C18 D-threo Ceramide (d18:1/18:0) A synthetic ceramide C18 D-threo Ceramide (d18:1/18:0) Chemical Structure
  45. GC49806 C18 Ganglioside GD3-d3 (ammonium salt) An internal standard for the quantification of ganglioside GD3 C18 Ganglioside GD3-d3 (ammonium salt) Chemical Structure
  46. GC43050 C18 L-erythro Ceramide (d18:1/18:0) C18 L-erythro Ceramide is a naturally occurring ceramide and stereoisomer of C18 ceramide. C18 L-erythro Ceramide (d18:1/18:0) Chemical Structure
  47. GC43051 C18 L-threo Ceramide (d18:1/18:0) C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. C18 L-threo Ceramide (d18:1/18:0) Chemical Structure
  48. GC43052 C18 Phytoceramide (t18:0/18:0) C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in S. C18 Phytoceramide (t18:0/18:0) Chemical Structure
  49. GC40141 C18 Phytoceramide-d3 (t18:0/18:0-d3) C18 Phytoceramide-d3 (t18:0/18:0-d3) is intended for use as an internal standard for the quantification of C18 phytoceramide (t18:0/18:0) by GC- or LC-MS. C18 Phytoceramide-d3 (t18:0/18:0-d3) Chemical Structure
  50. GC43069 C22 Ceramide (d18:1/22:0)

    C-22 ceramide is an endogenous bioactive sphingolipid.

     C22 Ceramide (d18:1/22:0) Chemical Structure
  51. GC43141 Carboxyatractyloside (potassium salt) Carboxyatractyloside is a natural heteroglucoside produced in some plants, including A. Carboxyatractyloside (potassium salt) Chemical Structure
  52. GC43195 CAY10703 Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. CAY10703 Chemical Structure
  53. GC47065 CAY10773 A derivative of sorafenib CAY10773 Chemical Structure
  54. GC14727 CCCP

    카보닐시아니드-3-클로로페닐하이드라존(CCCP)은 내부 미토콘드리아 막에서 양성자 그래디언트의 결합을 해제하여 ATP 합성 속도를 저해하는 프로토노 포어입니다.

     CCCP Chemical Structure
  55. GC65208 CCI-006 CCI-006은 미토콘드리아 호흡을 억제하여 MLL-r 백혈병 세포의 하위 집합에서 극복할 수 없는 미토콘드리아 탈분극 및 pro-apoptotic unfolded protein response(UPR)를 유발함으로써 MLL 재배열 백혈병 세포의 선택적 억제제 및 화학감작제입니다. CCI-006 Chemical Structure
  56. GC43289 Cochlioquinone B Cochlioquinone is a sesquiterpene metabolite originally isolated from C. Cochlioquinone B Chemical Structure
  57. GC47114 Coenzyme A (lithium salt hydrate) An essential cofactor in enzymatic acetyl transfer reactions Coenzyme A (lithium salt hydrate) Chemical Structure
  58. GC43295 Coenzyme A (sodium salt hydrate) Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A (sodium salt hydrate) Chemical Structure
  59. GC47116 Coenzyme Q10-d6

    CoQ10 양적 분석을 위한 내부 표준제

     Coenzyme Q10-d6 Chemical Structure
  60. GC43297 Coenzyme Q2 Coenzyme Q10 is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. Coenzyme Q2 Chemical Structure
  61. GC49454 Complex 3 A fluorescent copper complex with anticancer activity Complex 3 Chemical Structure
  62. GC47123 Coumarin-Quinone Conjugate A fluorescent substrate for NADH:ubiquinone oxidoreductases Coumarin-Quinone Conjugate Chemical Structure
  63. GC19138 CTPI-2 CTPI-2는 3.5μM의 KD를 갖는 3세대 미토콘드리아 시트레이트 운반체 SLC25A1 억제제입니다. CTPI-2 Chemical Structure
  64. GC43345 Cyclohexanoyl Coenzyme A Cyclohexanoyl coenzyme A (CHCoA) is an acyl CoA that contains a cyclohexane group. Cyclohexanoyl Coenzyme A Chemical Structure
  65. GC49863 Cytarabine 5′-monophosphate An active metabolite of cytarabine Cytarabine 5′-monophosphate Chemical Structure
  66. GC25337 D-Carnitine hydrochloride D-Carnitine hydrochloride ((S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride) is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids. D-Carnitine hydrochloride Chemical Structure
  67. GN10072 Daidzin Daidzin Chemical Structure
  68. GC40538 Decylubiquinone 데실루비퀴논은 유비퀴논(코엔자임 Q10)의 유사체입니다. Decylubiquinone Chemical Structure
  69. GC18869 Deoxyenterocin Deoxyenterocin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibiotic, antiviral, and antioxidant properties. Deoxyenterocin Chemical Structure
  70. GC49022 Didanosine-d2 An internal standard for the quantification of didanosine Didanosine-d2 Chemical Structure
  71. GC38620 Dihydrorotenone

    천연 살충제인 디하이드로로테논은 강력한 미토콘드리아 억제제입니다.

     Dihydrorotenone Chemical Structure
  72. GC43463 DiIC1(5) DiIC1(5) is a signal-off fluorescent probe for the detection of mitochondrial membrane potential disruption. DiIC1(5) Chemical Structure
  73. GC47238 Diquat (bromide) Diquat(브로마이드)는 원치 않는 잡초를 퇴치하기 위해 면화, 대두 및 기타 작물 재배에 일반적으로 사용되는 포괄적인 제초제입니다. Diquat (bromide) Chemical Structure
  74. GC43498 DL-α-Lipoic Acid DL-α-리포산은 미토콘드리아 효소 복합체의 필수 보조 인자인 항산화제입니다. DL-α-Lipoic Acid Chemical Structure
  75. GC47243 DL-Carnitine-d9 (chloride) An internal standard for the quantification of carnitine DL-Carnitine-d9 (chloride) Chemical Structure
  76. GC43543 DNP-INT DNP-INT is a quinone analog that inhibits electron transport in plants by competitively inhibiting plastoquinol oxidation by binding at the Qo site of cytochrome b6f (Kd = 1.4 nM). DNP-INT Chemical Structure
  77. GC18439 Doxorubicinone 독소루비시논은 항암 화학요법제 독소루비신의 대사 산물입니다. 독소루비신은 IC50이 각각 0.8μM 및 2.67μM인 강력한 인간 DNA 토포이소머라제 I 및 토포이소머라제 II 억제제입니다. Doxorubicinone Chemical Structure
  78. GC47274 DS44960156 DS44960156은 MTHFD2 및 MTHFD1에 대해 IC50 값이 각각 1.6μM 및 >30μM인 선택적 MTHFD2(Methylenetetrahydrofolate dehydrogenase 2) 억제제입니다. DS44960156 Chemical Structure
  79. GC18992 Duclauxin Duclauxin decreases proliferation of tumor cells in vitro and increases the lifespan of mice innoculated with Ehrlich ascitic tumor cells. Duclauxin Chemical Structure
  80. GC34569 Elamipretide TFA Elamipretide TFA Chemical Structure
  81. GC32858 ER-000444793 ER-000444793은 미토콘드리아 투과성 전이 기공(mPTP) 개방의 강력한 억제제입니다. ER-000444793은 2.8μM의 IC50으로 mPTP를 억제합니다. ER-000444793 Chemical Structure
  82. GC14328 FCCP

    FCCP는 양성자 운반체 (H+ 이온 포어)로, 플라즈마 막 및 미토콘드리아 막의 극화를 촉진하는 강력한 인산 제거 결합제입니다.

     FCCP Chemical Structure
  83. GC18641 Ferutinin 천연 테르페노이드 화합물인 페루티닌은 각각 33.1 nM 및 180.5 nM의 IC50을 갖는 에스트로겐 수용체 ERα 작용제 및 에스트로겐 ERβ-수용체 작용제/길항제입니다. Ferutinin Chemical Structure
  84. GC43664 Filipin II

    Filipin II is a polyene and an active component of the polyene antibiotic filipin complex.

     Filipin II Chemical Structure
  85. GC43713 Fura-FF (potassium salt) Fura-FF(칼륨염)는 칼슘용 저친화성 형광 염료입니다(Ex/Em: 칼슘 부재 시 365/514 nm, 높은 칼슘 농도 존재 시 339/507 nm). Fura-FF (potassium salt) Chemical Structure
  86. GC43714 Fura-FF AM Fura-FF AM is a cell-permeable acetoxymethyl ester of the fluorescence calcium indicator fura-FF (potassium salt). Fura-FF AM Chemical Structure
  87. GC40008 Fuscin Fuscin, 곰팡이 대사 산물, 항 HIV 효과가 있는 CCR5 수용체 길항제. Fuscin Chemical Structure
  88. GC43723 Galactosylsphingosine (d18:1) 갈락토세레브로시다제(GALC) 효소의 기질인 갈락토실스핑고신(d18:1)(갈락토실스핑고신)은 크라베병의 잠재적 바이오마커입니다. Galactosylsphingosine (d18:1) Chemical Structure
  89. GC43729 Ganglioside GD3 Mixture (sodium salt) Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. Ganglioside GD3 Mixture (sodium salt) Chemical Structure
  90. GC36132 Genistein 8-c-glucoside Genistein 8-c-glucoside(G8CG)는 글루코사이드입니다. Genistein 8-c-glucoside는 미토콘드리아 막 탈분극을 유도하고 세포 사멸을 유도합니다. Genistein 8-c-glucoside Chemical Structure
  91. GC47399 Geranylgeranoic Acid An isoprenoid with anticancer activity Geranylgeranoic Acid Chemical Structure
  92. GC61599 GW604714X GW604714X는 다른 기질이 아닌 피루브산에 의해 지원되는 미토콘드리아 호흡의 강력한 억제제입니다. GW604714X Chemical Structure
  93. GA10948 H-His-OH H-His-OH Chemical Structure
  94. GC40665 Harzianopyridone Harzianopyridone is an atpenin-like inhibitor of mammalian and nematode mitochondrial complex II (succinate:ubiquinone oxidoreductase; SQR) with IC50 values of 0.017, 0.2, and 2 μM for bovine, rat, and nematode complex II, respectively. Harzianopyridone Chemical Structure
  95. GC52219 Heptadecanoyl-L-carnitine (chloride) A long-chain acylcarnitine Heptadecanoyl-L-carnitine (chloride) Chemical Structure
  96. GC52231 Heptadecanoyl-L-carnitine-d3 (chloride) An internal standard for the quantification of heptadecanoyl-L-carnitine Heptadecanoyl-L-carnitine-d3 (chloride) Chemical Structure
  97. GC49479 Hypoxanthine-d4 An internal standard for the quantification of hypoxanthine Hypoxanthine-d4 Chemical Structure
  98. GC43887 IBTP (iodide) IBTP is a lipophilic cation that is accumulated in mitochondria and forms stable thioether adducts in a thiol-specific manner. IBTP (iodide) Chemical Structure
  99. GC49359 IM-156 (acetate) A mitochondrial complex I inhibitor and an AMPKα activator IM-156 (acetate) Chemical Structure
  100. GC10576 Imeglimin Imeglimin(EMD 387008)은 경구 혈당 강하제입니다. Imeglimin Chemical Structure
  101. GC10956 Imeglimin hydrochloride Imeglimin 염산염(EMD 387008)은 경구 혈당 강하제입니다. Imeglimin hydrochloride Chemical Structure

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